Past, Present, and Future Strategies for Enhanced Assessment of Embryo's Genome and Reproductive Competence in Women of Advanced Reproductive Age.
PGT
diagnostics
embryo (human)
genetics
in vitro fertilization (IVF)
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2019
2019
Historique:
received:
30
07
2018
accepted:
21
02
2019
entrez:
4
4
2019
pubmed:
4
4
2019
medline:
4
4
2019
Statut:
epublish
Résumé
Recent advancements in genomic analysis allow testing of an increasing number of genetic features in human preimplantation embryos. Typical single gene mutation and whole chromosomes testing can now be integrated with assessment of mitochondrial DNA and polygenic conditions. Diagnostic expansion into epigenetic and transcriptomic assessment in the near future are potential technological targets which may improve the prognostic outlook of patients of advanced reproductive age and overall
Identifiants
pubmed: 30941103
doi: 10.3389/fendo.2019.00154
pmc: PMC6433971
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
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