Iron Metabolism in Liver Cancer Stem Cells.
cancer stem cells
chelators
ferroptosis
iron
liver cancer
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2019
2019
Historique:
received:
21
12
2018
accepted:
22
02
2019
entrez:
4
4
2019
pubmed:
4
4
2019
medline:
4
4
2019
Statut:
epublish
Résumé
Cancer stem cells (CSC) which have been identified in several tumors, including liver cancer, represent a particular subpopulation of tumor cells characterized by properties similar to those of adult stem cells. Importantly, CSC are resistant to standard therapies, thereby leading to metastatic dissemination and tumor relapse. Given the increasing evidence that iron homeostasis is deregulated in cancer, here we describe the iron homeostasis alterations in cancer cells, particularly in liver CSC. We also discuss two paradoxically opposite iron manipulation-strategies for tumor therapy based either on iron chelation or iron overload-mediated oxidant production leading to ferroptosis. A better understanding of iron metabolism modifications occurring in hepatic tumors and particularly in liver CSC cells may offer new therapeutic options for this cancer, which is characterized by increasing incidence and unfavorable prognosis.
Identifiants
pubmed: 30941302
doi: 10.3389/fonc.2019.00149
pmc: PMC6433741
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
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