Exploiting Necroptosis for Therapy of Acute Lymphoblastic Leukemia.
apoptosis dysregulation
drug resistance
leukemia
necroptosis
necroptotic compounds
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2019
2019
Historique:
received:
02
12
2018
accepted:
05
03
2019
entrez:
4
4
2019
pubmed:
4
4
2019
medline:
4
4
2019
Statut:
epublish
Résumé
Escape from chemotherapy-induced apoptosis is a hallmark of drug resistance in cancer. The recent identification of alternative programmed cell death pathways opens up for possibilities to circumvent the apoptotic blockade in drug resistant cancer and eliminate malignant cells. Indeed, we have recently shown that programmed necrosis, termed necroptosis, could be triggered to induce cell death in a subgroup of primary acute lymphoblastic leukemia (ALL) including highly refractory relapsed cases. In this review we focus on molecular mechanisms that drive drug resistance in ALL of childhood and discuss the potential of necroptosis activation to eradicate resistant disease.
Identifiants
pubmed: 30941349
doi: 10.3389/fcell.2019.00040
pmc: PMC6433701
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
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