On the relationship between the heritability and the attributable fraction.
Journal
Human genetics
ISSN: 1432-1203
Titre abrégé: Hum Genet
Pays: Germany
ID NLM: 7613873
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
03
01
2019
accepted:
22
03
2019
pubmed:
4
4
2019
medline:
28
5
2019
entrez:
4
4
2019
Statut:
ppublish
Résumé
Heritability is the most commonly used measure of genetic contribution to disease outcomes. Being the fraction of the variance of latent trait liability attributable to genetic factors, heritability of binary traits is a difficult technical concept that is sometimes misinterpreted as the more-easily understandable concept of attributable fraction. In this paper we use the liability threshold model to describe the analytical relationship between heritability and attributable fraction. Towards this end, we consider a hypothetical intervention that is aimed to reduce the genetic risk of the disease for a specified target group of the population. We show how the relation between the heritability and the attributable fraction depends on the disease prevalence, the intervention effect and the size of the target group. We use two real examples to illustrate the practical implications of our theoretical results.
Identifiants
pubmed: 30941497
doi: 10.1007/s00439-019-02006-8
pii: 10.1007/s00439-019-02006-8
pmc: PMC6483966
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
425-435Subventions
Organisme : Vetenskapsråde
ID : 340-2013-5867
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