The role of the T-N tract in advanced stage tongue cancer.
compartmental tongue surgery
lingual lymph nodes
oral cancer
squamous cell carcinoma
tongue cancer
Journal
Head & neck
ISSN: 1097-0347
Titre abrégé: Head Neck
Pays: United States
ID NLM: 8902541
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
10
08
2018
revised:
11
03
2019
accepted:
18
03
2019
pubmed:
4
4
2019
medline:
24
11
2020
entrez:
4
4
2019
Statut:
ppublish
Résumé
We investigated the role of the soft tissue tract between the primary tumor and the neck lymph nodes, the "T-N tract," in patients with tongue squamous cell carcinoma at an advanced stage. We performed a compartmental tongue surgery in 233 patients. Cumulative incidence of relapses and overall survival curves were compared by T-N tract involvement. Multivariate Cox proportional hazards models were used to assess the independent role of T-N tract. At 4 years of follow-up, patients with disease in the T-N tract experienced a significantly more distant recurrence (40%) than did patients without T-N tract involvement (22%; P = .02). Multivariate Cox models indicate a significant almost triple risk of distant metastases (hazard ratio [HR], 2.70; 95% CI, 1.01-7.19; P = .05) and double risk of death (HR, 2.09; 95%CI, 1.13-3.85; P = .02) in patients with "T-N tract involvement." Our data show that the T-N tract plays an important role in prognosis and survival in patients with tongue cancer.
Sections du résumé
BACKGROUND
We investigated the role of the soft tissue tract between the primary tumor and the neck lymph nodes, the "T-N tract," in patients with tongue squamous cell carcinoma at an advanced stage.
METHODS
We performed a compartmental tongue surgery in 233 patients. Cumulative incidence of relapses and overall survival curves were compared by T-N tract involvement. Multivariate Cox proportional hazards models were used to assess the independent role of T-N tract.
RESULTS
At 4 years of follow-up, patients with disease in the T-N tract experienced a significantly more distant recurrence (40%) than did patients without T-N tract involvement (22%; P = .02). Multivariate Cox models indicate a significant almost triple risk of distant metastases (hazard ratio [HR], 2.70; 95% CI, 1.01-7.19; P = .05) and double risk of death (HR, 2.09; 95%CI, 1.13-3.85; P = .02) in patients with "T-N tract involvement."
CONCLUSIONS
Our data show that the T-N tract plays an important role in prognosis and survival in patients with tongue cancer.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2756-2767Subventions
Organisme : HPV-AHEAD
ID : FP7-HEALTH-2011-282562
Pays : International
Informations de copyright
© 2019 Wiley Periodicals, Inc.