Effect of Progression in Malnutrition and Inflammatory Conditions on Adverse Events and Mortality in Patients on Maintenance Hemodialysis.
Age Factors
Aged
Body Mass Index
Cardiovascular Diseases
/ blood
Disease Progression
Female
Humans
Infections
/ blood
Inflammation
/ blood
Kaplan-Meier Estimate
Male
Malnutrition
/ blood
Middle Aged
Nutritional Status
Prospective Studies
Renal Dialysis
/ adverse effects
Serum Albumin, Human
/ analysis
Adverse events
Chronic inflammation
Hemodialysis
Malnutrition
Journal
Blood purification
ISSN: 1421-9735
Titre abrégé: Blood Purif
Pays: Switzerland
ID NLM: 8402040
Informations de publication
Date de publication:
2019
2019
Historique:
pubmed:
4
4
2019
medline:
3
9
2019
entrez:
4
4
2019
Statut:
ppublish
Résumé
In maintenance hemodialysis (MHD), protein-energy malnutrition and chronic inflammation can be critical and are two of the main causes of mortality. We compared the change in nutrition and inflammatory conditions between younger and older MHD patients during a 2-year period. Furthermore, using Kaplan-Meier analysis, we evaluated the correlations between changes in each parameter and any adverse events. During the observational period, body mass index (BMI) and serum albumin levels decreased significantly in older patients. In Kaplan-Meier analysis, patients who showed a decline in BMI had an associated elevated risk for cerebro-cardiovascular disease and hospitalization. Moreover, patients who showed a decline in albumin also had an associated higher risk for infectious disease and hospitalization. This study revealed that the downward trend in nutritional status was prominent in elderly patients. Furthermore, changes in nutritional and inflammatory conditions during MHD were associated with adverse events in MHD patients.
Sections du résumé
BACKGROUND/AIM
In maintenance hemodialysis (MHD), protein-energy malnutrition and chronic inflammation can be critical and are two of the main causes of mortality.
METHOD
We compared the change in nutrition and inflammatory conditions between younger and older MHD patients during a 2-year period. Furthermore, using Kaplan-Meier analysis, we evaluated the correlations between changes in each parameter and any adverse events.
RESULT
During the observational period, body mass index (BMI) and serum albumin levels decreased significantly in older patients. In Kaplan-Meier analysis, patients who showed a decline in BMI had an associated elevated risk for cerebro-cardiovascular disease and hospitalization. Moreover, patients who showed a decline in albumin also had an associated higher risk for infectious disease and hospitalization.
CONCLUSION
This study revealed that the downward trend in nutritional status was prominent in elderly patients. Furthermore, changes in nutritional and inflammatory conditions during MHD were associated with adverse events in MHD patients.
Identifiants
pubmed: 30943483
pii: 000496629
doi: 10.1159/000496629
doi:
Substances chimiques
Serum Albumin, Human
ZIF514RVZR
Types de publication
Journal Article
Multicenter Study
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
3-11Informations de copyright
© 2019 S. Karger AG, Basel.