Perinatal factors affect the gut microbiota up to four years after birth.
Anti-Bacterial Agents
/ pharmacology
Bacteria
/ classification
Child, Preschool
Feces
/ microbiology
Female
Gastrointestinal Microbiome
/ drug effects
Gastrointestinal Tract
/ microbiology
Humans
Infant
Infant, Newborn
Male
Microbiota
/ physiology
Pregnancy
/ drug effects
Premature Birth
RNA, Ribosomal, 16S
/ genetics
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
03 04 2019
03 04 2019
Historique:
received:
10
10
2018
accepted:
28
02
2019
entrez:
5
4
2019
pubmed:
5
4
2019
medline:
30
4
2019
Statut:
epublish
Résumé
Perinatal factors impact gut microbiota development in early life, however, little is known on the effects of these factors on microbes in later life. Here we sequence DNA from faecal samples of children over the first four years and reveal a perpetual evolution of the gut microbiota during this period. The significant impact of gestational age at birth and delivery mode on gut microbiota progression is evident in the first four years of life, while no measurable effects of antibiotics are found in the first year. Microbiota profiles are also characteristic in children dependant on gestational age and maturity. Full term delivery is characterised by Bacteroides (year one), Parabacteroides (year two) and Christensenellaceae (year four). Preterm delivery is characterised by Lactobacillus (year one), Streptococcus (year two) and Carnobacterium (year four). This study reveals that the gut retains distinct microbial profiles of perinatal factors up to four years of age.
Identifiants
pubmed: 30944304
doi: 10.1038/s41467-019-09252-4
pii: 10.1038/s41467-019-09252-4
pmc: PMC6447568
doi:
Substances chimiques
Anti-Bacterial Agents
0
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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