3D Synthetic Peptide-based Architectures for the Engineering of the Enteric Nervous System.
Animals
Cell Differentiation
/ physiology
Cell Survival
/ physiology
Cells, Cultured
Enteric Nervous System
/ metabolism
Insulin-Like Growth Factor I
/ metabolism
Mice
Nerve Growth Factor
/ metabolism
Neurogenesis
/ physiology
Neurons
/ metabolism
Neurotrophin 3
/ metabolism
Peptides
/ metabolism
RNA, Messenger
/ metabolism
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
03 04 2019
03 04 2019
Historique:
received:
25
07
2018
accepted:
22
03
2019
entrez:
5
4
2019
pubmed:
5
4
2019
medline:
7
10
2020
Statut:
epublish
Résumé
Damage of enteric neurons and partial or total loss of selective neuronal populations are reported in intestinal disorders including inflammatory bowel diseases and necrotizing enterocolitis. To develop three-dimensional scaffolds for enteric neurons we propose the decoration of ionic-complementary self-assembling peptide (SAP) hydrogels, namely EAK or EAbuK, with bioactive motives. Our results showed the ability of EAK in supporting neuronal cell attachment and neurite development. Therefore, EAK was covalently conjugated to: RGD, (GRGDSP)
Identifiants
pubmed: 30944410
doi: 10.1038/s41598-019-42071-7
pii: 10.1038/s41598-019-42071-7
pmc: PMC6447567
doi:
Substances chimiques
Neurotrophin 3
0
Peptides
0
RNA, Messenger
0
Insulin-Like Growth Factor I
67763-96-6
Nerve Growth Factor
9061-61-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5583Références
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