Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2.

Animals Antigens / administration & dosage Crohn Disease / immunology Female Gastrointestinal Microbiome / immunology Homeostasis / immunology Humans Immunity, Innate / immunology Inflammation / immunology Interleukin-1beta / immunology Interleukin-2 / deficiency Intestine, Small / cytology Intestines / cytology Macrophages / immunology Male Mice Myeloid Differentiation Factor 88 / deficiency Nod2 Signaling Adaptor Protein / deficiency T-Lymphocytes, Regulatory / classification

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
04 2019
Historique:
received: 29 06 2018
accepted: 28 02 2019
pubmed: 5 4 2019
medline: 27 11 2019
entrez: 5 4 2019
Statut: ppublish

Résumé

Interleukin (IL)-2 is a pleiotropic cytokine that is necessary to prevent chronic inflammation in the gastrointestinal tract

Identifiants

DOI: 10.1038/s41586-019-1082-x PMID: 30944470 PMC: PMC6481643
pubmed: 30944470
doi: 10.1038/s41586-019-1082-x
pii: 10.1038/s41586-019-1082-x
pmc: PMC6481643
mid: NIHMS1522936
doi:

Substances chimiques

Antigens 0
Interleukin-1beta 0
Interleukin-2 0
Myd88 protein, mouse 0
Myeloid Differentiation Factor 88 0
Nod2 Signaling Adaptor Protein 0
Nod2 protein, mouse 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

405-409

Subventions

Organisme : NIDDK NIH HHS
ID : R21 DK110262
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI145989
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI123368
Pays : United States
Organisme : NIH HHS
ID : DP5 OD012116
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK126871
Pays : United States
Organisme : NIAID NIH HHS
ID : F32 AI124517
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI143842
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI095608
Pays : United States

Commentaires et corrections

Type : CommentIn

Références

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Auteurs

Lei Zhou (L)

Division of Gastroenterology, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.

Coco Chu (C)

Division of Gastroenterology, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.

Fei Teng (F)

Division of Gastroenterology, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.

Nicholas J Bessman (NJ)

Division of Gastroenterology, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.

Jeremy Goc (J)

Division of Gastroenterology, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.

Endi K Santosa (EK)

Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.

Gregory G Putzel (GG)

Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.

Hiroki Kabata (H)

Division of Gastroenterology, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.

Judith R Kelsen (JR)

Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Robert N Baldassano (RN)

Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Manish A Shah (MA)

Weill Cornell Medicine, New York Presbyterian Hospital, New York, NY, USA.

Robbyn E Sockolow (RE)

Department of Pediatrics, Division of Gastroenterology and Nutrition, Weill Cornell Medicine, Cornell University, New York, NY, USA.

Eric Vivier (E)

APHM, CIML, Hôpital de la Timone, Immunologie, Marseille Immunopole, Aix Marseille University, Marseille, France.
Innate Pharma Research Laboratories, Innate Pharma, Marseille, France.

Gérard Eberl (G)

Microenvironment and Immunity Unit, Institut Pasteur, Paris, France.

Kendall A Smith (KA)

Division of Immunology, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.

Gregory F Sonnenberg (GF)

Division of Gastroenterology, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA. gfsonnenberg@med.cornell.edu.
Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA. gfsonnenberg@med.cornell.edu.
Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA. gfsonnenberg@med.cornell.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Innate lymphoid cells support regulatory T...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Innate lymphoid cells support regulatory T...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies inflammatoires intestinales › Maladie de Crohn › Innate lymphoid cells support regulatory T...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Innate lymphoid cells support regulatory T...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Innate lymphoid cells support regulatory T...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Innate lymphoid cells support regulatory T...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › Innate lymphoid cells support regulatory T...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Innate lymphoid cells support regulatory T...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Monokines › Interleukine-1 › Interleukine-1 bêta › Innate lymphoid cells support regulatory T...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Interleukine-2 › Innate lymphoid cells support regulatory T...
questionsmedicales.fr › Système digestif › Tube digestif › Intestins › Intestin grêle › Innate lymphoid cells support regulatory T...
questionsmedicales.fr › Système digestif › Tube digestif › Intestins › Innate lymphoid cells support regulatory T...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Innate lymphoid cells support regulatory T...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Innate lymphoid cells support regulatory T...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Facteur de différenciation myéloïde-88 › Innate lymphoid cells support regulatory T...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Protéines adaptatrices de signalisation CARD › Protéine adaptatrice de signalisation NOD2 › Innate lymphoid cells support regulatory T...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Innate lymphoid cells support regulatory T...