Genomewide association study for C-reactive protein in Indians replicates known associations of common variants.
Adult
Biomarkers
/ analysis
C-Reactive Protein
/ analysis
Case-Control Studies
Female
Follow-Up Studies
Genome-Wide Association Study
Humans
India
/ epidemiology
Inflammation
/ blood
Male
Metabolic Diseases
/ blood
Middle Aged
Polymorphism, Single Nucleotide
Prognosis
Risk Factors
White People
/ statistics & numerical data
Journal
Journal of genetics
ISSN: 0973-7731
Titre abrégé: J Genet
Pays: India
ID NLM: 2985113R
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
entrez:
5
4
2019
pubmed:
5
4
2019
medline:
10
7
2019
Statut:
ppublish
Résumé
Elevated C-reactive protein (CRP) serves as an independent biomarker for acute and chronic inflammation, and is also associated with metabolic diseases. Genomewide loci regulating CRP level in Indian population, a high-risk group for metabolic illness, is unexplored. Therefore, we aimed to discover common polymorphisms associated with plasma CRP level in 4493 Indians of Indo-European origin using genomewide association study. Genomewide strong associations of two known intronic variants in hepatocyte nuclear factor-1 α gene (
Substances chimiques
Biomarkers
0
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
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