Tunable Supramolecular Gel Properties by Varying Thermal History.

hydrogels peptide amphiphiles self-assembly supramolecular chemistry thermal history

Journal

Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783

Informations de publication

Date de publication:
12 Jun 2019
Historique:
received: 19 12 2018
pubmed: 5 4 2019
medline: 5 4 2019
entrez: 5 4 2019
Statut: ppublish

Résumé

The possibility of using differential pre-heating prior to supramolecular gelation to control the balance between hydrogen-bonding and aromatic stacking interactions in supramolecular gels and obtain consequent systematic regulation of structure and properties is demonstrated. Using a model aromatic peptide amphiphile, Fmoc-tyrosyl-leucine (Fmoc-YL) and a combination of fluorescence, infrared, circular dichroism and NMR spectroscopy, it is shown that the balance of these interactions can be adjusted by temporary exposure to elevated temperatures in the range 313-365 K, followed by supramolecular locking in the gel state by cooling to room temperature. Distinct regimes can be identified regarding the balance between H-bonding and aromatic stacking interactions, with a transition point at 333 K. Consequently, gels can be obtained with customizable properties, including supramolecular chirality and gel stiffness. The differential supramolecular structures also result in changes in proteolytic stability, highlighting the possibility of obtaining a range of supramolecular architectures from a single molecular structure by simply controlling the pre-assembly temperature.

Identifiants

DOI: 10.1002/chem.201806281 PMID: 30945773
pubmed: 30945773
doi: 10.1002/chem.201806281
doi:

Types de publication

Journal Article

Langues

eng

Pagination

7881-7887

Subventions

Organisme : FP7 Ideas: European Research Council
ID : 258775

Informations de copyright

© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Auteurs

Sisir Debnath (S)

WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, UK.
Current Address: Department of Chemistry, Serampore College, 9, William Carey Sarani, Serampore, Hooghly, West Bengal, Pin-712201, India.

Sangita Roy (S)

WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, UK.

Yousef M Abul-Haija (YM)

WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, UK.
Current Address: WestCHEM, School of Chemistry, University of Glasgow, Glasgow, G12 8QQ, UK.
ORCID: 0000-0002-0357-0653

Pim W J M Frederix (PWJM)

WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, UK.
SUPA, Department of Physics, University of Strathclyde, 107 Rottenrow East, Glasgow, G4 0NG, UK.

Susana M Ramalhete (SM)

School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.

Andrew R Hirst (AR)

WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, UK.
Current Address: Department of Chemistry, University of York, York, YO10 5DD, UK.

Nadeem Javid (N)

WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, UK.
Current Address: School of Chemistry and Biosciences, University of Bradford, Bradford, BD7 1DP, UK.

Neil T Hunt (NT)

SUPA, Department of Physics, University of Strathclyde, 107 Rottenrow East, Glasgow, G4 0NG, UK.
Current Address: Department of Chemistry, University of York, York, YO10 5DD, UK.

Sharon M Kelly (SM)

Institute of Molecular Cell and Systems Biology, University of Glasgow, Glasgow, G12 8QQ, UK.

Jesús Angulo (J)

School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.

Yaroslav Z Khimyak (YZ)

School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.

Rein V Ulijn (RV)

WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, UK.
Advanced Science Research Center (ASRC) at the Graduate Center of the City University of New York (CUNY), 85 St Nicholas Terrace, New York, 10031, USA.
Department of Chemistry, Hunter College, City University of New York, 695 Park Avenue, New York, 10065, USA.
Ph.D. programs in Biochemistry and Chemistry, The Graduate Center of the City University of New York, New York, 10016, USA.

Classifications MeSH