Segment-specific association of carotid-intima-media thickness with cardiovascular risk factors - findings from the STAAB cohort study.
Adult
Aged
Carotid Arteries
/ diagnostic imaging
Carotid Artery Diseases
/ diagnostic imaging
Carotid Intima-Media Thickness
Diabetes Mellitus
/ diagnosis
Dyslipidemias
/ diagnosis
Female
Germany
/ epidemiology
Humans
Hypertension
/ diagnosis
Male
Middle Aged
Obesity
/ diagnosis
Predictive Value of Tests
Prevalence
Prognosis
Risk Assessment
Risk Factors
Smoking
/ adverse effects
Cardiovascular risk factors
Cardiovascular risk prediction
Carotid intima-media thickness (CIMT)
Carotid segment
Carotid ultrasound
Journal
BMC cardiovascular disorders
ISSN: 1471-2261
Titre abrégé: BMC Cardiovasc Disord
Pays: England
ID NLM: 100968539
Informations de publication
Date de publication:
04 04 2019
04 04 2019
Historique:
received:
07
11
2018
accepted:
14
03
2019
entrez:
6
4
2019
pubmed:
6
4
2019
medline:
28
1
2020
Statut:
epublish
Résumé
The guideline recommendation to not measure carotid intima-media thickness (CIMT) for cardiovascular risk prediction is based on the assessment of just one single carotid segment. We evaluated whether there is a segment-specific association between different measurement locations of CIMT and cardiovascular risk factors. Subjects from the population-based STAAB cohort study comprising subjects aged 30 to 79 years of the general population from Würzburg, Germany, were investigated. CIMT was measured on the far wall of both sides in three different predefined locations: common carotid artery (CCA), bulb, and internal carotid artery (ICA). Diabetes, dyslipidemia, hypertension, smoking, and obesity were considered as risk factors. In multivariable logistic regression analysis, odds ratios of risk factors per location were estimated for the endpoint of individual age- and sex-adjusted 75th percentile of CIMT. 2492 subjects were included in the analysis. Segment-specific CIMT was highest in the bulb, followed by CCA, and lowest in the ICA. Dyslipidemia, hypertension, and smoking were associated with CIMT, but not diabetes and obesity. We observed no relevant segment-specific association between the three different locations and risk factors, except for a possible interaction between smoking and ICA. As no segment-specific association between cardiovascular risk factors and CIMT became evident, one simple measurement of one location may suffice to assess the cardiovascular risk of an individual.
Sections du résumé
BACKGROUND
The guideline recommendation to not measure carotid intima-media thickness (CIMT) for cardiovascular risk prediction is based on the assessment of just one single carotid segment. We evaluated whether there is a segment-specific association between different measurement locations of CIMT and cardiovascular risk factors.
METHODS
Subjects from the population-based STAAB cohort study comprising subjects aged 30 to 79 years of the general population from Würzburg, Germany, were investigated. CIMT was measured on the far wall of both sides in three different predefined locations: common carotid artery (CCA), bulb, and internal carotid artery (ICA). Diabetes, dyslipidemia, hypertension, smoking, and obesity were considered as risk factors. In multivariable logistic regression analysis, odds ratios of risk factors per location were estimated for the endpoint of individual age- and sex-adjusted 75th percentile of CIMT.
RESULTS
2492 subjects were included in the analysis. Segment-specific CIMT was highest in the bulb, followed by CCA, and lowest in the ICA. Dyslipidemia, hypertension, and smoking were associated with CIMT, but not diabetes and obesity. We observed no relevant segment-specific association between the three different locations and risk factors, except for a possible interaction between smoking and ICA.
CONCLUSIONS
As no segment-specific association between cardiovascular risk factors and CIMT became evident, one simple measurement of one location may suffice to assess the cardiovascular risk of an individual.
Identifiants
pubmed: 30947692
doi: 10.1186/s12872-019-1044-0
pii: 10.1186/s12872-019-1044-0
pmc: PMC6449987
doi:
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
84Références
JAMA. 2012 Aug 22;308(8):796-803
pubmed: 22910757
JAMA. 2007 Mar 28;297(12):1344-53
pubmed: 17384434
J Am Soc Echocardiogr. 2013 Jun;26(6):667-73
pubmed: 23611058
Hypertension. 2015 Apr;65(4):707-13
pubmed: 25624341
Circulation. 2007 Jan 30;115(4):459-67
pubmed: 17242284
Eur Heart J. 2002 Jun;23(12):934-40
pubmed: 12069447
Stroke. 2010 Jan;41(1):9-15
pubmed: 19910544
AJNR Am J Neuroradiol. 2010 Nov;31(10):1951-5
pubmed: 20864519
Arterioscler Thromb Vasc Biol. 1999 Dec;19(12):3007-13
pubmed: 10591682
Am J Cardiol. 2002 Nov 1;90(9):953-8
pubmed: 12398961
Eur J Prev Cardiol. 2017 Mar;24(5):468-479
pubmed: 27879413
Circulation. 2004 Jun 15;109(23 Suppl 1):III33-8
pubmed: 15198964
Stroke. 2000 Mar;31(3):574-81
pubmed: 10700488
J Am Soc Echocardiogr. 2008 Feb;21(2):93-111; quiz 189-90
pubmed: 18261694
Atherosclerosis. 2016 Sep;252:207-274
pubmed: 27664503
J Am Soc Echocardiogr. 2013 Dec;26(12):1457-64
pubmed: 24050846
Cerebrovasc Dis. 2012;34(4):290-6
pubmed: 23128470
Int J Cardiovasc Imaging. 2018 Jul;34(7):1057-1065
pubmed: 29445974
Atherosclerosis. 2013 May;228(1):1-11
pubmed: 23395523
Atherosclerosis. 2006 Jan;184(1):201-6
pubmed: 15907856
BMC Cardiovasc Disord. 2017 Nov 2;17(1):276
pubmed: 29096615
Circulation. 2014 Jun 24;129(25 Suppl 2):S49-73
pubmed: 24222018
Stroke. 1993 Sep;24(9):1297-304
pubmed: 8362421
Atherosclerosis. 2001 Feb 1;154(2):437-48
pubmed: 11166777
Stroke. 2006 Jan;37(1):87-92
pubmed: 16339465
Eur Heart J. 2010 Mar;31(5):614-22
pubmed: 19952003
Clin Physiol Funct Imaging. 2016 Jan;36(1):25-32
pubmed: 25216303
Stroke. 2010 Oct;41(10):2375-7
pubmed: 20814002
J Am Coll Cardiol. 2014 Jun 3;63(21):2301-2
pubmed: 24613323
Am J Cardiol. 2011 Jun 15;107(12):1841-7
pubmed: 21481827
PLoS One. 2012;7(4):e35332
pubmed: 22496918
J Am Heart Assoc. 2018 May 8;7(10):
pubmed: 29739796
Atherosclerosis. 2011 Jun;216(2):359-64
pubmed: 21376319
Atherosclerosis. 2016 Mar;246:29-35
pubmed: 26752690
Neth J Med. 2004 Jul-Aug;62(7):235-41
pubmed: 15554598