Hepatobiliary Complications in Critically Ill Patients.

Cholestasis, Intrahepatic / etiology Critical Illness Humans Hypoxia / complications Liver Failure, Acute / etiology Systemic Inflammatory Response Syndrome / complications
Acute liver failure Acute liver injury Cholestatic liver injury Critical illness Hepatobiliary Hypoxic liver injury

Journal

Clinics in liver disease
ISSN: 1557-8224
Titre abrégé: Clin Liver Dis
Pays: United States
ID NLM: 9710002

Informations de publication

Date de publication:
05 2019
Historique:
entrez: 6 4 2019
pubmed: 6 4 2019
medline: 18 12 2019
Statut: ppublish

Résumé

Critically ill patients frequently present with the systemic inflammatory response syndrome, which is largely a reflection of the liver's response to injury. Underlying hepatic congestion is a major risk factor for hypoxic liver injury, the most common cause for hepatocellular injury. Cholestatic liver injury often occurs in critically ill patients due to inhibition of farnesoid X receptor (FXR), the main regulator of bile acid handling, particularly in the liver and intestines. Additional injury to the liver occurs due to alterations in the bile acid pool with increased cytotoxic forms and disturbance in the typical processing of xenobiotics in the liver.

Identifiants

DOI: 10.1016/j.cld.2018.12.005 PMID: 30947873
pubmed: 30947873
pii: S1089-3261(18)30109-0
doi: 10.1016/j.cld.2018.12.005
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

221-232

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

Auteurs

Amanda Cheung (A)

Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 750 Welch Road, Suite 210, Palo Alto, CA 94304, USA. Electronic address: cheungac@stanford.edu.

Steven Flamm (S)

Division of Gastroenterology and Hepatology, Northwestern Feinberg School of Medicine, 19-046 Arkes Building, 676 North Saint Clair, Chicago, IL 60611, USA.

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Classifications MeSH

questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Cholestase intrahépatique › Hepatobiliary Complications in Critically Ill Patients.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie grave › Hepatobiliary Complications in Critically Ill Patients.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Hepatobiliary Complications in Critically Ill Patients.
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Hypoxie › Hepatobiliary Complications in Critically Ill Patients.
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Insuffisance hépatique › Défaillance hépatique › Défaillance hépatique aigüe › Hepatobiliary Complications in Critically Ill Patients.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Choc › Syndrome de réponse inflammatoire généralisée › Hepatobiliary Complications in Critically Ill Patients.