Study of potential biomedical application of sol-gel derived Zn-doped SiO
Actin Cytoskeleton
/ drug effects
Animals
Anti-Bacterial Agents
/ pharmacology
Bacillus subtilis
/ drug effects
Biomedical Technology
/ methods
Cell Death
/ drug effects
Cell Division
Cell Line
Cell Nucleus
/ drug effects
Cell Survival
/ drug effects
Cellulose
/ analogs & derivatives
Differential Thermal Analysis
Escherichia coli
/ drug effects
Fibroblasts
/ cytology
Mice
Microbial Sensitivity Tests
Nanoparticles
/ chemistry
Silicon Dioxide
/ chemistry
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Zinc
/ chemistry
Antibacterial properties
Biomedical application
Silica hybrid materials
Sol-gel method
Journal
Materials science & engineering. C, Materials for biological applications
ISSN: 1873-0191
Titre abrégé: Mater Sci Eng C Mater Biol Appl
Pays: Netherlands
ID NLM: 101484109
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
12
11
2018
revised:
14
02
2019
accepted:
04
03
2019
entrez:
6
4
2019
pubmed:
6
4
2019
medline:
26
7
2019
Statut:
ppublish
Résumé
A series of Zn-doped hybrid materials based on silica from tetraethoxysilane (TEOS) and hydroxypropyl cellulose (HPC) were prepared by a sol-gel route. The structure, morphology and thermal behavior of synthesized hybrids were characterized by infrared (IR) spectroscopy, ultraviolet-visible spectroscopy (UV-Vis), transmission electron microscopy (TEM) and differential thermal analysis with thermogravimetric analysis (DTA/TG). The obtained materials were investigated for a potential biomedical application. The antibacterial properties of hybrids were investigated by measuring the inhibition zones formed around the materials containing different zinc content in presence of reference strains of Gram-positive and Gram-negative bacteria. The biocompatibility tests showed no cytotoxicity and genotoxicity, as well as no changes in actin cytoskeleton organization for hybrids with Zn content below 5 wt%.
Identifiants
pubmed: 30948097
pii: S0928-4931(18)33468-4
doi: 10.1016/j.msec.2019.03.018
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Silicon Dioxide
7631-86-9
Cellulose
9004-34-6
hydroxypropylcellulose
9XZ8H6N6OH
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Langues
eng
Pagination
608-615Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.