Randomized trial comparing standard vs sequential high-dose chemotherapy for inducing early CR in adult AML.

Adolescent Adult Aged Antineoplastic Combined Chemotherapy Protocols / therapeutic use Cytarabine / administration & dosage Etoposide / administration & dosage Female Hematopoietic Stem Cell Transplantation / methods Humans Idarubicin / administration & dosage Induction Chemotherapy / methods Leukemia, Myeloid, Acute / drug therapy Male Middle Aged Remission Induction / methods Survival Analysis

Journal

Blood advances

ISSN: 2473-9537

Titre abrégé: Blood Adv

Pays: United States

ID NLM: 101698425

Informations de publication

Date de publication:
09 04 2019

Historique:

received: 26 09 2018

accepted: 23 02 2019

entrez: 6 4 2019

pubmed: 6 4 2019

medline: 24 7 2020

Statut: ppublish

Résumé

Here we evaluated whether sequential high-dose chemotherapy (sHD) increased the early complete remission (CR) rate in acute myelogenous leukemia (AML) compared with standard-intensity idarubicin-cytarabine-etoposide (ICE) chemotherapy. This study enrolled 574 patients (age, 16-73 years; median, 52 years) who were randomly assigned to ICE (n = 286 evaluable) or sHD (2 weekly 3-day blocks with cytarabine 2 g/m

Identifiants

DOI: 10.1182/bloodadvances.2018026625 PMID: 30948365 PMC: PMC6457212

pubmed: 30948365

pii: bloodadvances.2018026625

doi: 10.1182/bloodadvances.2018026625

pmc: PMC6457212

doi:

Substances chimiques

Cytarabine 04079A1RDZ

Etoposide 6PLQ3CP4P3

Idarubicin ZRP63D75JW

Banques de données

ClinicalTrials.gov

['NCT00495287']

Types de publication

Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

1103-1117

Informations de copyright

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