DNA (de)methylation in embryonic stem cells controls CTCF-dependent chromatin boundaries.
5-Methylcytosine
/ chemistry
Animals
CCCTC-Binding Factor
/ metabolism
Cell Line
DNA Methylation
DNA-Binding Proteins
/ genetics
Dioxygenases
Epigenesis, Genetic
Insulator Elements
/ genetics
Mice
Mice, Inbred C57BL
Mouse Embryonic Stem Cells
/ enzymology
Nucleosomes
/ enzymology
Proto-Oncogene Proteins
/ genetics
Journal
Genome research
ISSN: 1549-5469
Titre abrégé: Genome Res
Pays: United States
ID NLM: 9518021
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
18
05
2018
accepted:
27
03
2019
pubmed:
6
4
2019
medline:
28
11
2019
entrez:
6
4
2019
Statut:
ppublish
Résumé
Coordinated changes of DNA (de)methylation, nucleosome positioning, and chromatin binding of the architectural protein CTCF play an important role for establishing cell-type-specific chromatin states during differentiation. To elucidate molecular mechanisms that link these processes, we studied the perturbed DNA modification landscape in mouse embryonic stem cells (ESCs) carrying a double knockout (DKO) of the
Identifiants
pubmed: 30948436
pii: gr.239707.118
doi: 10.1101/gr.239707.118
pmc: PMC6499307
doi:
Substances chimiques
CCCTC-Binding Factor
0
DNA-Binding Proteins
0
Nucleosomes
0
Proto-Oncogene Proteins
0
TET1 protein, mouse
0
5-Methylcytosine
6R795CQT4H
Dioxygenases
EC 1.13.11.-
Tet2 protein, mouse
EC 1.13.11.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
750-761Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 200733/Z/16/Z
Pays : United Kingdom
Informations de copyright
© 2019 Wiehle et al.; Published by Cold Spring Harbor Laboratory Press.
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