DPPA2 and DPPA4 are necessary to establish a 2C-like state in mouse embryonic stem cells.
Animals
Chromatin
/ metabolism
Embryonic Development
/ genetics
Gene Expression Regulation, Developmental
/ genetics
Genome
/ genetics
Mice
Mouse Embryonic Stem Cells
/ metabolism
Nuclear Proteins
/ metabolism
Oocytes
/ metabolism
Retroelements
/ genetics
Transcription Factors
/ metabolism
Transcription, Genetic
/ genetics
Transcriptional Activation
/ genetics
Zygote
/ metabolism
DPPA2
DPPA4
DUX
LINE‐1
zygotic genome activation
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
09
11
2018
revised:
07
03
2019
accepted:
11
03
2019
pubmed:
6
4
2019
medline:
1
5
2020
entrez:
6
4
2019
Statut:
ppublish
Résumé
After fertilization of the transcriptionally silent oocyte, expression from both parental chromosomes is launched through zygotic genome activation (ZGA), occurring in the mouse at the 2-cell (2C) stage. Among the first elements to be transcribed are the
Identifiants
pubmed: 30948459
pii: embr.201847382
doi: 10.15252/embr.201847382
pmc: PMC6500978
pii:
doi:
Substances chimiques
Chromatin
0
Dppa2 protein, mouse
0
Dppa4 protein, mouse
0
Nuclear Proteins
0
Retroelements
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2019 The Authors. Published under the terms of the CC BY NC ND 4.0 license.
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