Pathological Crying and Laughing in Motor Neuron Disease: Pathobiology, Screening, Intervention.
amyotrophic lateral sclerosis
biomarkers
emotional lability
involuntary emotional expression disorder
magnetic resonance imaging
motor neuron disease
pathological crying and laughing
pseudobulbar affect
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2019
2019
Historique:
received:
20
12
2018
accepted:
26
02
2019
entrez:
6
4
2019
pubmed:
6
4
2019
medline:
6
4
2019
Statut:
epublish
Résumé
Pathological crying and laughing (PCL) has significant quality-of-life implications in amyotrophic lateral sclerosis (ALS); it can provoke restrictive life-style modifications and lead to social isolation. Despite its high prevalence and quality of life implications, it remains surprisingly understudied. Divergent pathophysiological models have been proposed, centered on corticobulbar tract degeneration, prefrontal cortex pathology, sensory deafferentation, and impaired cerebellar gate-control mechanisms. Quantitative MRI techniques and symptom-specific clinical instruments offer unprecedented opportunities to elucidate the anatomical underpinnings of PCL pathogenesis. Emerging neuroimaging studies of ALS support the role of cortico-pontine-cerebellar network dysfunction in context-inappropriate emotional responses. The characterization of PCL-associated pathophysiological processes is indispensable for the development of effective pharmacological therapies.
Identifiants
pubmed: 30949121
doi: 10.3389/fneur.2019.00260
pmc: PMC6438102
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
260Références
Int J Geriatr Psychiatry. 1999 Aug;14(8):681-5
pubmed: 10489659
J Neurol Sci. 1999 Oct 31;169(1-2):22-5
pubmed: 10540003
J Neurol Sci. 1999 Oct 31;169(1-2):43-8
pubmed: 10540006
Brain. 2001 Sep;124(Pt 9):1708-19
pubmed: 11522574
J Neurol Neurosurg Psychiatry. 2001 Nov;71(5):615-20
pubmed: 11606672
Mov Disord. 2001 Sep;16(5):867-75
pubmed: 11746616
Mov Disord. 2002 May;17(3):622-4
pubmed: 12112225
Psychiatry Res. 2003 Jul 30;123(3):207-11
pubmed: 12928109
Brain. 1956 Dec;79(4):589-609
pubmed: 13396065
Neurology. 1992 Oct;42(10):1918-23
pubmed: 1407573
J Chem Neuroanat. 2003 Dec;26(4):331-43
pubmed: 14729135
J Neurol Neurosurg Psychiatry. 2004 Jun;75(6):921-3
pubmed: 15146017
Brain. 2004 Jul;127(Pt 7):1507-17
pubmed: 15163610
Neurology. 2004 Oct 26;63(8):1364-70
pubmed: 15505150
Amyotroph Lateral Scler Other Motor Neuron Disord. 2004 Sep;5 Suppl 1:99-102
pubmed: 15512885
J Neuropsychiatry Clin Neurosci. 2004 Fall;16(4):426-34
pubmed: 15616168
Lancet Neurol. 2005 May;4(5):270
pubmed: 15847840
CNS Spectr. 2005 May;10(5):1-14; quiz 15-6
pubmed: 15962457
Clin Pharmacol Ther. 1992 Jun;51(6):647-55
pubmed: 1611804
Clin Neuropharmacol. 2005 Sep-Oct;28(5):249-51
pubmed: 16239769
Stroke. 2006 Jan;37(1):156-61
pubmed: 16306470
Psychol Med. 2006 Jun;36(6):865-75
pubmed: 16490122
Ann Neurol. 2006 May;59(5):780-7
pubmed: 16634036
J Physiol. 2006 Jul 15;574(Pt 2):491-507
pubmed: 16709640
CNS Spectr. 2006 Jun;11(S6):1-7
pubmed: 16816786
Expert Opin Pharmacother. 2006 Dec;7(18):2581-98
pubmed: 17150011
Mov Disord. 2007 Apr 30;22(6):798-803
pubmed: 17290465
J Neuropsychiatry Clin Neurosci. 2007 Spring;19(2):187-90
pubmed: 17431066
Eur J Neurol. 2007 Aug;14(8):940-3
pubmed: 17662020
Arch Neurol. 2008 Feb;65(2):264-6
pubmed: 18268198
J Neurol. 2008 Mar;255(3):406-12
pubmed: 18297331
Eur J Neurol. 2008 May;15(5):497-500
pubmed: 18325023
J Neurol Sci. 2008 Aug 15;271(1-2):137-47
pubmed: 18504049
J Neurol Sci. 2009 Mar 15;278(1-2):16-20
pubmed: 19103449
Drugs Today (Barc). 2008 Sep;44(9):661-8
pubmed: 19137121
Parkinsonism Relat Disord. 2009 Aug;15(7):511-5
pubmed: 19181560
J Neuropsychiatry Clin Neurosci. 2009 Winter;21(1):75-87
pubmed: 19359455
Amyotroph Lateral Scler. 2010;11(1-2):52-6
pubmed: 19714539
Cortex. 2010 Jul-Aug;46(7):831-44
pubmed: 20152963
Cochrane Database Syst Rev. 2010 Feb 17;(2):CD003690
pubmed: 20166068
J Comp Neurol. 1991 Feb 15;304(3):502-15
pubmed: 2022761
Ann Neurol. 2010 Nov;68(5):693-702
pubmed: 20839238
Expert Rev Neurother. 2011 Jul;11(7):1077-88
pubmed: 21539437
Adv Ther. 2011 Jul;28(7):586-601
pubmed: 21660634
Acta Neuropathol. 2011 Dec;122(6):691-702
pubmed: 22101323
Brain. 2011 Dec;134(Pt 12):3458-69
pubmed: 22155983
Neurobiol Aging. 2013 Feb;34(2):419-27
pubmed: 22608240
Adv Ther. 2012 Sep;29(9):775-98
pubmed: 22941524
J Neurol Neurosurg Psychiatry. 2013 Jul;84(7):766-73
pubmed: 23085933
Neurology. 2013 Jul 23;81(4):361-9
pubmed: 23771489
Amyotroph Lateral Scler Frontotemporal Degener. 2013 Dec;14(7-8):507-15
pubmed: 23889583
P T. 2013 Jun;38(6):325-8
pubmed: 23946627
PLoS One. 2013 Aug 21;8(8):e72232
pubmed: 23991068
Cerebellum. 2014 Feb;13(1):151-77
pubmed: 23996631
Ther Clin Risk Manag. 2013;9:483-9
pubmed: 24348042
Neuroimage Clin. 2014 Feb 27;4:436-43
pubmed: 24624329
Neurology. 2014 Aug 12;83(7):620-7
pubmed: 25008395
J Neurol Neurosurg Psychiatry. 2015 Apr;86(4):468-70
pubmed: 25053771
Neuropsychiatr Dis Treat. 2014 Jun 26;10:1161-74
pubmed: 25061302
Acta Neuropsychiatr. 2013 Dec;25(6):361-6
pubmed: 25287877
Neuropsychiatr Dis Treat. 2014 Oct 07;10:1903-10
pubmed: 25336956
Singapore Med J. 2015 Apr;56(4):e71-3
pubmed: 25917480
Acta Clin Croat. 2015 Jun;54(2):159-63
pubmed: 26415311
J Neurol. 2016 Feb;263(2):316-321
pubmed: 26588919
J Stroke Cerebrovasc Dis. 2016 Mar;25(3):556-64
pubmed: 26683594
J Clin Mov Disord. 2015 Aug 14;2:13
pubmed: 26788349
BMC Neurol. 2016 Jun 09;16:89
pubmed: 27276999
J Neurol. 2016 Sep;263(9):1788-95
pubmed: 27314961
J Neurol Neurosurg Psychiatry. 1989 Apr;52(4):523-5
pubmed: 2738597
Genet Med. 2017 Jan;19(1):69-76
pubmed: 27388693
CNS Spectr. 2016 Dec;21(S1):34-44
pubmed: 28044945
Cochrane Database Syst Rev. 2017 Jan 10;1:CD011776
pubmed: 28072907
Acta Neurol Scand. 1989 Aug;80(2):114-7
pubmed: 2816272
Case Rep Oncol Med. 2017;2017:8120689
pubmed: 28377827
J Neurol Neurosurg Psychiatry. 2017 Oct;88(10):825-831
pubmed: 28572273
J Clin Neurosci. 2017 Nov;45:159-161
pubmed: 28887071
Amyotroph Lateral Scler Frontotemporal Degener. 2018 Feb;19(1-2):12-20
pubmed: 29034720
Amyotroph Lateral Scler Frontotemporal Degener. 2018 Feb;19(1-2):4-6
pubmed: 29092641
J Neuropsychiatry Clin Neurosci. 2018 Summer;30(3):214-219
pubmed: 29505320
Curr Opin Neurol. 2018 Aug;31(4):431-438
pubmed: 29750730
Brain Res. 1985 Apr 8;331(2):195-207
pubmed: 3986565
Stroke. 1994 May;25(5):1050-2
pubmed: 7818634
Lancet. 1993 Oct 2;342(8875):837-9
pubmed: 8104273
Am J Psychiatry. 1993 Feb;150(2):286-93
pubmed: 8422080
Neurosurgery. 1995 Nov;37(5):885-93
pubmed: 8559336
Neurol Neurochir Pol. 1995 Sep-Oct;29(5):663-74
pubmed: 8584093
J Neurol Neurosurg Psychiatry. 1996 Nov;61(5):531-3
pubmed: 8937357
Clin Neuropharmacol. 1996 Dec;19(6):532-5
pubmed: 8937793
J Neurol Neurosurg Psychiatry. 1997 May;62(5):464-72
pubmed: 9153602
J Neurol Neurosurg Psychiatry. 1997 Jul;63(1):89-93
pubmed: 9221973
Brain. 1998 Apr;121 ( Pt 4):561-79
pubmed: 9577385
J Neurol Neurosurg Psychiatry. 1998 Dec;65(6):928-9
pubmed: 9854975