Prevalence and role of HER2 mutations in cancer.
Afatinib
HER2 mutations
Neratinib
Next-generation sequencing (NGS)
TCGA
Journal
Pharmacology & therapeutics
ISSN: 1879-016X
Titre abrégé: Pharmacol Ther
Pays: England
ID NLM: 7905840
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
28
02
2019
accepted:
27
03
2019
pubmed:
6
4
2019
medline:
28
4
2020
entrez:
6
4
2019
Statut:
ppublish
Résumé
HER2 activating mutations act as oncogenic drivers in various cancer types. In the clinic, they can be identified by next generation sequencing (NGS) in either tumor biopsies or circulating cell-free DNA (cfDNA). Preclinical data indicate that HER2 "hot spot" mutations are constitutively active, have transforming capacity in vitro and in vivo and show variable sensitivity to anti-HER2 based therapies. Recent clinical trials also revealed activity of HER2-targeted drugs against a variety of tumors harboring HER2 mutations. Here, we review the prevalence and type of HER2 mutations identified in different human cancers, their biochemical and biological characterization, and their sensitivity to anti HER2-based therapies in both preclinical and clinical settings.
Identifiants
pubmed: 30951733
pii: S0163-7258(19)30057-9
doi: 10.1016/j.pharmthera.2019.03.010
pmc: PMC6571037
mid: NIHMS1526022
pii:
doi:
Substances chimiques
Receptor, ErbB-2
EC 2.7.10.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
188-196Subventions
Organisme : NCI NIH HHS
ID : T32 CA160001
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA176067
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : R03 CA187094
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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