Polyarteritis Nodosa Neurologic Manifestations.

Central Nervous System Diseases / etiology Humans Male Peripheral Nervous System Diseases / etiology Polyarteritis Nodosa / complications
ANCA Hepatitis B virus Peripheral neuropathy Polyarteritis nodosa Stroke Vasculitis

Journal

Neurologic clinics
ISSN: 1557-9875
Titre abrégé: Neurol Clin
Pays: United States
ID NLM: 8219232

Informations de publication

Date de publication:
05 2019
Historique:
entrez: 7 4 2019
pubmed: 7 4 2019
medline: 29 8 2019
Statut: ppublish

Résumé

Polyarteritis nodosa (PAN) is a necrotizing vasculitis affecting medium-sized vessels whose main manifestations are weight loss, fever, peripheral neuropathy, renal, musculoskeletal, gastrointestinal tract and/or cutaneous involvement(s), hypertension and/or cardiac failure. Peripheral neuropathy is one of the most frequent and earliest symptoms, affecting 50% to 75% of PAN patients. Central nervous system involvement affects only 2% to 10% of PAN patients, often late during the disease course. Treatment relies on combining corticosteroids and an immunosuppressant (mainly cyclophosphamide) in patients with poor prognoses. In patients with hepatitis B virus-related PAN, plasma exchanges and antiviral drugs should be combined with corticosteroids.

Identifiants

DOI: 10.1016/j.ncl.2019.01.007 PMID: 30952413
pubmed: 30952413
pii: S0733-8619(19)30007-6
doi: 10.1016/j.ncl.2019.01.007
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

345-357

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Hubert de Boysson (H)

Department of Internal Medicine, Centre Hospitalier Universitaire de Caen, Caen, France.

Loïc Guillevin (L)

Vasculitides and Scleroderma, Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, Université Paris Descartes, 27, rue Fg Saint-Jacques, Paris 75679 Cedex 14, France. Electronic address: loic.guillevin@aphp.fr.

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Classifications MeSH

questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Polyarteritis Nodosa Neurologic Manifestations.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Polyarteritis Nodosa Neurologic Manifestations.
questionsmedicales.fr › Maladies du système nerveux › Maladies neuromusculaires › Neuropathies périphériques › Polyarteritis Nodosa Neurologic Manifestations.
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Dermatoses vasculaires › Polyartérite noueuse › Polyarteritis Nodosa Neurologic Manifestations.