Asymmetric ephaptic inhibition between compartmentalized olfactory receptor neurons.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
05 04 2019
05 04 2019
Historique:
received:
21
08
2018
accepted:
04
03
2019
entrez:
7
4
2019
pubmed:
7
4
2019
medline:
10
5
2019
Statut:
epublish
Résumé
In the Drosophila antenna, different subtypes of olfactory receptor neurons (ORNs) housed in the same sensory hair (sensillum) can inhibit each other non-synaptically. However, the mechanisms underlying this underexplored form of lateral inhibition remain unclear. Here we use recordings from pairs of sensilla impaled by the same tungsten electrode to demonstrate that direct electrical ("ephaptic") interactions mediate lateral inhibition between ORNs. Intriguingly, within individual sensilla, we find that ephaptic lateral inhibition is asymmetric such that one ORN exerts greater influence onto its neighbor. Serial block-face scanning electron microscopy of genetically identified ORNs and circuit modeling indicate that asymmetric lateral inhibition reflects a surprisingly simple mechanism: the physically larger ORN in a pair corresponds to the dominant neuron in ephaptic interactions. Thus, morphometric differences between compartmentalized ORNs account for highly specialized inhibitory interactions that govern information processing at the earliest stages of olfactory coding.
Identifiants
pubmed: 30952860
doi: 10.1038/s41467-019-09346-z
pii: 10.1038/s41467-019-09346-z
pmc: PMC6451019
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1560Subventions
Organisme : NIGMS NIH HHS
ID : P41 GM103412
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC015519
Pays : United States
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