Genetic Network Analysis to Assess the Risk of Human Immunodeficiency Virus Transmission Among Men Who Have Sex With Men Seeking Partners on the Internet.
HIV
MSM
internet
online partner seeking
transmission network
Journal
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
ISSN: 1537-6591
Titre abrégé: Clin Infect Dis
Pays: United States
ID NLM: 9203213
Informations de publication
Date de publication:
14 02 2020
14 02 2020
Historique:
received:
13
12
2018
accepted:
01
04
2019
pubmed:
7
4
2019
medline:
7
1
2021
entrez:
7
4
2019
Statut:
ppublish
Résumé
Online partner seeking (OPS) among men who have sex with men (MSM) is associated with increased risk behavior including frequency of unprotected anal intercourse, number of partners, and incidence of sexually transmitted infections (STIs). However, the impact on transmission of human immunodeficiency virus (HIV) is uncertain. MSM diagnosed with acute and early HIV infection were recruited from the Primary Infection Resource Consortium. HIV transmission events in the year following infection were inferred using estimated date of infection combined with genetic network analysis with linked sequences defined as ≤0.015 sequences/site difference in the HIV type 1 (HIV-1) pol coding region. Participants completed a detailed baseline questionnaire including reported methods of meeting sexual partners, including OPS, in the prior 3 months, and regression was performed with inferred transmission as the outcome. From 147 MSM who completed the questionnaire, there were an associated 20 inferred HIV transmissions. No association with OPS was found (odds ratio, 0.64 [95% confidence interval, .24-1.69]; P = .37), though individuals who reported OPS were more likely to have reported a greater number of partners (P = .003) and prior STIs (P = .002). Geospatial analysis did not indicate that OPS was associated with increased geographical reach of the user (P = .68). Individuals reporting OPS did not have increased odds of inferred HIV-1 transmission in the year following infection using genetic linkage analysis despite apparently increased risk behavior. OPS also did not increase the geographic distance between genetically clustered HIV infections, suggesting that individuals mainly use the internet to meet partners in their local region.
Sections du résumé
BACKGROUND
Online partner seeking (OPS) among men who have sex with men (MSM) is associated with increased risk behavior including frequency of unprotected anal intercourse, number of partners, and incidence of sexually transmitted infections (STIs). However, the impact on transmission of human immunodeficiency virus (HIV) is uncertain.
METHODS
MSM diagnosed with acute and early HIV infection were recruited from the Primary Infection Resource Consortium. HIV transmission events in the year following infection were inferred using estimated date of infection combined with genetic network analysis with linked sequences defined as ≤0.015 sequences/site difference in the HIV type 1 (HIV-1) pol coding region. Participants completed a detailed baseline questionnaire including reported methods of meeting sexual partners, including OPS, in the prior 3 months, and regression was performed with inferred transmission as the outcome.
RESULTS
From 147 MSM who completed the questionnaire, there were an associated 20 inferred HIV transmissions. No association with OPS was found (odds ratio, 0.64 [95% confidence interval, .24-1.69]; P = .37), though individuals who reported OPS were more likely to have reported a greater number of partners (P = .003) and prior STIs (P = .002). Geospatial analysis did not indicate that OPS was associated with increased geographical reach of the user (P = .68).
CONCLUSIONS
Individuals reporting OPS did not have increased odds of inferred HIV-1 transmission in the year following infection using genetic linkage analysis despite apparently increased risk behavior. OPS also did not increase the geographic distance between genetically clustered HIV infections, suggesting that individuals mainly use the internet to meet partners in their local region.
Identifiants
pubmed: 30953067
pii: 5429566
doi: 10.1093/cid/ciz278
pmc: PMC7319271
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
925-932Subventions
Organisme : NICHD NIH HHS
ID : R21 HD094646
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI131971
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007384
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI134295
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI036214
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI131385
Pays : United States
Informations de copyright
© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
Références
J Acquir Immune Defic Syndr. 2014 Jan 1;65(1):115-21
pubmed: 24419067
AIDS Behav. 2012 May;16(4):807-17
pubmed: 21748276
J Acquir Immune Defic Syndr. 2007 Feb 1;44(2):235-43
pubmed: 17179769
AIDS Behav. 2014 Aug;18(8):1523-31
pubmed: 24165985
J Urban Health. 2008 Sep;85(5):744-58
pubmed: 18649141
Arch Sex Behav. 2017 May;46(4):1079-1087
pubmed: 27671781
Sex Transm Dis. 2016 Jun;43(6):360-4
pubmed: 27200520
J Acquir Immune Defic Syndr. 2017 Jul 1;75 Suppl 3:S288-S295
pubmed: 28604430
Clin Infect Dis. 2015 Aug 1;61(3):468-75
pubmed: 25904374
AIDS Behav. 2015 Jun;19 Suppl 2:90-7
pubmed: 25566762
J Acquir Immune Defic Syndr. 2017 Jan 1;74(1):15-20
pubmed: 27552158
AIDS Behav. 2010 Dec;14(6):1353-61
pubmed: 20665100
AIDS Behav. 2007 Jul;11(4):522-6
pubmed: 17347876
Public Health Rep. 2016 Mar-Apr;131(2):264-71
pubmed: 26957661
AIDS Educ Prev. 2010 Dec;22(6):496-508
pubmed: 21204626
BMC Public Health. 2014 May 26;14:508
pubmed: 24885058
Arch Sex Behav. 2006 Aug;35(4):473-81
pubmed: 16933107
AIDS Behav. 2015 Oct;19(10):1905-13
pubmed: 25777506
Arch Sex Behav. 2015 Feb;44(2):443-51
pubmed: 25245930
PLoS One. 2014 Jun 05;9(6):e98443
pubmed: 24901437
Sex Transm Infect. 2014 Nov;90(7):567-72
pubmed: 24926041
AIDS. 2005 Jun 10;19(9):961-8
pubmed: 15905678
J Acquir Immune Defic Syndr. 2014 Dec 15;67(5):564-8
pubmed: 25226209
Arch Sex Behav. 2017 May;46(4):1061-1068
pubmed: 26987977
Sex Transm Infect. 2008 Feb;84(1):8-13
pubmed: 18003707
Clin Infect Dis. 2019 Apr 24;68(9):1539-1546
pubmed: 30169606
AIDS Care. 2007 Jul;19(6):822-7
pubmed: 17573604
Clin Infect Dis. 2018 Jun 18;67(1):105-111
pubmed: 29293891
N Engl J Med. 2013 Jan 17;368(3):218-30
pubmed: 23323898
AIDS. 2009 Nov 27;23(18):2497-506
pubmed: 19834319
Mol Biol Evol. 2018 Jul 1;35(7):1812-1819
pubmed: 29401317
Sex Transm Infect. 2014 Jun;90(4):290-6
pubmed: 24518249
Sci Rep. 2016 May 16;6:25927
pubmed: 27181715
Ann Intern Med. 2010 Jun 15;152(12):778-85
pubmed: 20547906
J Sex Res. 2014;51(4):390-409
pubmed: 24754360