Circadian rhythms: a possible new player in non-alcoholic fatty liver disease pathophysiology.
Circadian rhythms
Hepatocellular carcinoma (HCC)
Insulin resistance
Metabolic syndrome
Metabolism
Non-alcoholic fatty liver disease (NAFLD)
Non-alcoholic steatohepatitis (NASH)
Journal
Journal of molecular medicine (Berlin, Germany)
ISSN: 1432-1440
Titre abrégé: J Mol Med (Berl)
Pays: Germany
ID NLM: 9504370
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
07
12
2018
accepted:
13
03
2019
revised:
10
03
2019
pubmed:
7
4
2019
medline:
20
6
2020
entrez:
7
4
2019
Statut:
ppublish
Résumé
Over the last decades, a better knowledge of the molecular machinery supervising the regulation of circadian clocks has been achieved, and numerous findings have helped in unravelling the outstanding significance of the molecular clock for the proper regulation of our physiologic and metabolic homeostasis. Non-alcoholic fatty liver disease (NAFLD) is currently considered as one of the emerging liver pathologies in the Western countries due to the modification of eating habits and lifestyle. Although NAFLD is considered a pretty benign condition, it can progress towards non-alcoholic steatohepatitis (NASH) and eventually hepatocellular carcinoma (HCC). The pathogenic mechanisms involved in NAFLD development are complex, since this disease is a multifactorial condition. Major metabolic deregulations along with a genetic background are believed to take part in this process. In this light, the aim of this review is to give a comprehensive description of how our circadian machinery is regulated and to describe to what extent our internal clock is involved in the regulation of hormonal and metabolic homeostasis, and by extension in the development and progression of NAFLD/NASH and eventually in the onset of HCC.
Identifiants
pubmed: 30953079
doi: 10.1007/s00109-019-01780-2
pii: 10.1007/s00109-019-01780-2
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
741-759Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : Investigator Grant (IG) 2015 Id.17758
Pays : International
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