Treg cells in autoimmunity: from identification to Treg-based therapies.
Autoimmunity
Foxp3
Regulatory T cells
Journal
Seminars in immunopathology
ISSN: 1863-2300
Titre abrégé: Semin Immunopathol
Pays: Germany
ID NLM: 101308769
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
12
02
2019
accepted:
22
03
2019
pubmed:
7
4
2019
medline:
2
4
2020
entrez:
7
4
2019
Statut:
ppublish
Résumé
Regulatory (Treg) cells are key regulators of inflammation and important for immune tolerance and homeostasis. A major progress has been made in the identification and classification of Treg cells. Due to technological advances, we have gained deep insights in the epigenetic regulation of Treg cells. The use of fate reporter mice allowed addressing the functional consequences of loss of Foxp3 expression. Depending on the environment Treg cells gain effector functions upon loss of Foxp3 expression. However, the traditional view that Treg cells become necessarily pathogenic by gaining effector functions was challenged by recent findings and supports the notion of Treg cell lineage plasticity. Treg cell stability is also a major issue for Treg cell therapies. Clinical trials are designed to use polyclonal Treg cells as therapeutic tools. Here, we summarize the role of Treg cells in selected autoimmune diseases and recent advances in the field of Treg targeted therapies.
Identifiants
pubmed: 30953162
doi: 10.1007/s00281-019-00741-8
pii: 10.1007/s00281-019-00741-8
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
301-314Références
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