Insufficient sensitivity of laser desorption-time of flight mass spectrometry-based detection of hemozoin for malaria screening.

Hemeproteins / analysis Humans Malaria / epidemiology Mass Screening / methods Plasmodium / isolation & purification Sensitivity and Specificity Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
LD-TOF Malaria Mass spectrometry Plasmodium Rapid diagnostic test Tropics

Journal

Journal of microbiological methods
ISSN: 1872-8359
Titre abrégé: J Microbiol Methods
Pays: Netherlands
ID NLM: 8306883

Informations de publication

Date de publication:
05 2019
Historique:
received: 13 02 2019
revised: 27 03 2019
accepted: 02 04 2019
pubmed: 7 4 2019
medline: 11 6 2020
entrez: 7 4 2019
Statut: ppublish

Résumé

Laser desorption-time of flight (LD-TOF) mass spectrometry-based detection of hemozoin was assessed for its performance characteristics as a rapid screening test for malaria. In spite of good specificity of >95%, poor sensitivity of 80.2% for microscopically positive samples makes the easy-to-apply and rapid approach unsuitable for the routine diagnostic setting.

Identifiants

DOI: 10.1016/j.mimet.2019.04.002 PMID: 30953660
pubmed: 30953660
pii: S0167-7012(19)30121-6
doi: 10.1016/j.mimet.2019.04.002
pii:
doi:

Substances chimiques

Hemeproteins 0
hemozoin 39404-00-7

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

104-106

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Martin Christner (M)

Department of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Hagen Frickmann (H)

Department of Microbiology and Hospital Hygiene, Bundeswehr Hospital Hamburg, Hamburg, Germany; Institute for Medical Microbiology, Virology and Hygiene, University Medicine Rostock, Rostock, Germany. Electronic address: frickmann@bnitm.de.

Eva Klupp (E)

Department of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Holger Rohde (H)

Department of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Maya Kono (M)

Bernhard Nocht Institute for Tropical Medicine Hamburg, Hamburg, Germany.

Egbert Tannich (E)

Bernhard Nocht Institute for Tropical Medicine Hamburg, Hamburg, Germany.

Sven Poppert (S)

Swiss Tropical and Public Health Institute, Basel, Switzerland; Faculty of Medicine, University Basel, Basel, Switzerland.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Insufficient sensitivity of laser...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Insufficient sensitivity of laser...
questionsmedicales.fr › Infection › Maladies vectorielles › Paludisme › Insufficient sensitivity of laser...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pratiques en santé publique › Dépistage de masse › Insufficient sensitivity of laser...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Haemosporida › Plasmodium › Insufficient sensitivity of laser...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Sensibilité et spécificité › Insufficient sensitivity of laser...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse MALDI › Insufficient sensitivity of laser...