Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells.
Animals
Cell Differentiation
Cell Proliferation
Cells, Cultured
Cerebellum
/ metabolism
Encephalomyelitis, Autoimmune, Experimental
/ metabolism
Female
Mice, Inbred C57BL
Mitosis
Oligodendroglia
/ metabolism
Sirtuin 1
/ genetics
Sirtuin 2
/ metabolism
Sirtuins
/ metabolism
Stem Cells
/ metabolism
White Matter
/ metabolism
Experimental autoimmune encephalomyelitis
Multiple sclerosis
OPC
Remyelination
SIRT1
Sirtuins
Journal
Neuroscience letters
ISSN: 1872-7972
Titre abrégé: Neurosci Lett
Pays: Ireland
ID NLM: 7600130
Informations de publication
Date de publication:
21 06 2019
21 06 2019
Historique:
received:
23
11
2018
revised:
28
03
2019
accepted:
02
04
2019
pubmed:
7
4
2019
medline:
6
2
2020
entrez:
7
4
2019
Statut:
ppublish
Résumé
In multiple sclerosis (MS) regeneration of oligodendrocytes following inflammatory demyelination is limited by the compromised ability of progenitors to repopulate lesioned areas and transition to functionally competent oligodendrocytes. Regarding underlying mechanisms, the involvement of epigenetic processes has been suggested, e.g. the contribution of histone deacetylases (HDAC) known to regulate oligodendrocyte progenitor cell (OPC) differentiation. However, their precise expression patterns, particular of redox-sensitive NAD
Identifiants
pubmed: 30953735
pii: S0304-3940(19)30235-6
doi: 10.1016/j.neulet.2019.04.007
pii:
doi:
Substances chimiques
Sirt6 protein, mouse
EC 2.4.2.31
Sirt1 protein, mouse
EC 3.5.1.-
Sirt2 protein, mouse
EC 3.5.1.-
Sirtuin 1
EC 3.5.1.-
Sirtuin 2
EC 3.5.1.-
Sirtuins
EC 3.5.1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
116-125Informations de copyright
Copyright © 2019. Published by Elsevier B.V.