Antibacterial bibenzyl derivatives from the tubers of Bletilla striata.
Antibacterial activities
Bibenzyl derivatives
Bletilla striata
Minimum inhibitory concentration (MIC)
Orchidaceae
Journal
Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
29
09
2018
revised:
25
03
2019
accepted:
26
03
2019
pubmed:
7
4
2019
medline:
17
5
2019
entrez:
7
4
2019
Statut:
ppublish
Résumé
Ten previously undescribed bibenzyl derivatives (bletistrins A-J), including 5 that have hydroxyl-substituted chiral centres on the aliphatic bibenzyl bridge, along with twelve known bibenzyl derivatives, were isolated from the rhizomes of Bletilla striata. The structures of bletistrins A-J were primarily elucidated on the basis of their 1D and 2D NMR spectroscopic data. The absolute configurations of bletistrins A, D, F, H and I were determined by electronic circular dichroism (ECD) spectroscopic analysis and optical rotation value. Most of the isolated compounds were evaluated for their antibacterial activities against 3 g-positive bacterial strains and 1 g-negative bacterial strain. Bletistrins F, G, and J, bulbocol, shanciguol and shancigusin B showed inhibitory activities, with MICs of (3-28 μg/mL) against S. aureus ATCC 6538.
Identifiants
pubmed: 30953908
pii: S0031-9422(18)30610-1
doi: 10.1016/j.phytochem.2019.03.022
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bibenzyls
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
216-223Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.