Imaging biomarkers of vulnerable carotid plaques for stroke risk prediction and their potential clinical implications.

Biomarkers Carotid Artery Diseases / diagnostic imaging Humans Plaque, Atherosclerotic / diagnosis Predictive Value of Tests Stroke / diagnosis

Journal

The Lancet. Neurology
ISSN: 1474-4465
Titre abrégé: Lancet Neurol
Pays: England
ID NLM: 101139309

Informations de publication

Date de publication:
06 2019
Historique:
received: 23 05 2018
revised: 03 01 2019
accepted: 04 01 2019
pubmed: 8 4 2019
medline: 17 6 2020
entrez: 8 4 2019
Statut: ppublish

Résumé

Stroke represents a massive public health problem. Carotid atherosclerosis plays a fundamental part in the occurence of ischaemic stroke. European and US guidelines for prevention of stroke in patients with carotid plaques are based on quantification of the percentage reduction in luminal diameter due to the atherosclerotic process to select the best therapeutic approach. However, better strategies for prevention of stroke are needed because some subtypes of carotid plaques (eg, vulnerable plaques) can predict the occurrence of stroke independent of the degree of stenosis. Advances in imaging techniques have enabled routine characterisation and detection of the features of carotid plaque vulnerability. Intraplaque haemorrhage is accepted by neurologists and radiologists as one of the features of vulnerable plaques, but other characteristics-eg, plaque volume, neovascularisation, and inflammation-are promising as biomarkers of carotid plaque vulnerability. These biomarkers could change current management strategies based merely on the degree of stenosis.

Identifiants

DOI: 10.1016/S1474-4422(19)30035-3 PMID: 30954372
pubmed: 30954372
pii: S1474-4422(19)30035-3
doi: 10.1016/S1474-4422(19)30035-3
pii:
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

559-572

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Luca Saba (L)

Department of Medical Sciences, University of Cagliari, Cagliari, Italy. Electronic address: lucasaba@tiscali.it.

Tobias Saam (T)

Department of Radiology, University Hospital Munich, Ludwig-Maximilians-University Munich, Munich, Germany; Radiologisches Zentrum Rosenheim, Rosenheim, Germany.

H Rolf Jäger (HR)

Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, University College London Institute of Neurology, London, UK.

Chun Yuan (C)

Department of Radiology, University of Washington, Seattle, WA, USA.

Thomas S Hatsukami (TS)

Department of Surgery, University of Washington, Seattle, WA, USA.

David Saloner (D)

Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.

Bruce A Wasserman (BA)

The Russell H Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins Hospital, Baltimore, MD, USA.

Leo H Bonati (LH)

Department of Neurology and Stroke Center, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.

Max Wintermark (M)

Department of Radiology, Neuroradiology Division, Stanford University, Stanford, CA, USA.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Imaging biomarkers of vulnerable carotid...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Artériopathies carotidiennes › Imaging biomarkers of vulnerable carotid...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Imaging biomarkers of vulnerable carotid...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Plaque d'athérosclérose › Imaging biomarkers of vulnerable carotid...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Valeur prédictive des tests › Imaging biomarkers of vulnerable carotid...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Imaging biomarkers of vulnerable carotid...