Modulation of mitochondrial dysfunction for treatment of disease.
Biogenesis
Dynamics
Energetics
Mitochondria
ROS
Journal
Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377
Informations de publication
Date de publication:
01 06 2019
01 06 2019
Historique:
received:
07
01
2019
revised:
21
03
2019
accepted:
25
03
2019
pubmed:
8
4
2019
medline:
12
9
2020
entrez:
8
4
2019
Statut:
ppublish
Résumé
Mitochondrial dysfunction is a causative and/or exacerbating feature of many pathologies. We discuss below approaches to modulate mitochondrial dysfunction that involve (1) increasing their energetic efficiency by targeting gene expression regulators such as PPAR or AMPK, (2) using antioxidant compounds to reduce the toxic reactive oxygen species mitochondria produce under stress, or (3) modulating aspects on the innate mitochondrial quality control system. The latter comprise linked processes of biogenesis, dynamic morphological changes, and elimination of defective mitochondria by mitophagy. We discuss representative compounds in all three classes.
Identifiants
pubmed: 30954429
pii: S0960-894X(19)30180-5
doi: 10.1016/j.bmcl.2019.03.041
pii:
doi:
Substances chimiques
Antioxidants
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1270-1277Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.