Evaluation of toxicokinetics of nonylphenol in the adult female Sprague-Dawley rats using a physiologically based toxicokinetic model.
Nonylphenol
Oral exposure
PBTK
Physiologically based toxicokinetic model
Rats
Risk assessment
Journal
Regulatory toxicology and pharmacology : RTP
ISSN: 1096-0295
Titre abrégé: Regul Toxicol Pharmacol
Pays: Netherlands
ID NLM: 8214983
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
21
12
2018
revised:
02
03
2019
accepted:
31
03
2019
pubmed:
8
4
2019
medline:
10
7
2019
entrez:
8
4
2019
Statut:
ppublish
Résumé
The physiologically based toxicokinetic (PBTK) model was firstly developed in female rats to quantitatively evaluate toxicokinetics of nonylphenol (NP). Changes in NP serum concentrations over time of single oral NP administration experiments in Sprague-Dawley rats and literature data were collected to establish and calibrate the PBTK model in the SimBiology framework. The calibrated model predicted the serum and tissue NP concentrations of repeat oral NP administration for model evaluation. NP concentrations in serum and tissues (liver, kidneys, adipose, brain, uterus and ovaries) were quantified using ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The model output of the time course data (values are within the standard deviation defined for each data point) indicated proximity of predictions to reality. The coefficients of determination r
Identifiants
pubmed: 30954491
pii: S0273-2300(19)30091-1
doi: 10.1016/j.yrtph.2019.03.019
pii:
doi:
Substances chimiques
Phenols
0
nonylphenol
79F6A2ILP5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
42-50Informations de copyright
Copyright © 2019. Published by Elsevier Inc.