Atrophic and hypertrophic photoaging: Clinical, histologic, and molecular features of 2 distinct phenotypes of photoaged skin.
Aged
Aged, 80 and over
Atrophy
/ genetics
Biopsy
Carcinoma, Basal Cell
/ epidemiology
Carcinoma, Squamous Cell
/ epidemiology
Collagen
/ genetics
Face
Female
Gene Expression
Humans
Hypertrophy
/ genetics
Incidence
Keratosis, Actinic
/ epidemiology
Keratosis, Seborrheic
/ epidemiology
Life Style
Male
Matrix Metalloproteinases
/ genetics
Middle Aged
Phenotype
Skin
/ metabolism
Skin Aging
/ genetics
Skin Neoplasms
/ epidemiology
Surveys and Questionnaires
Telangiectasis
/ epidemiology
Ultraviolet Rays
/ adverse effects
aging
elastosis
photoaging
skin cancer
telangiectasia
wrinkles
Journal
Journal of the American Academy of Dermatology
ISSN: 1097-6787
Titre abrégé: J Am Acad Dermatol
Pays: United States
ID NLM: 7907132
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
03
08
2018
revised:
17
01
2019
accepted:
08
03
2019
pubmed:
8
4
2019
medline:
21
12
2019
entrez:
8
4
2019
Statut:
ppublish
Résumé
Exposure to the sun causes premature skin aging, known as photoaging. Clinical features of photoaging vary widely among individuals. In one form, skin appears thin with telangiectasia, and in another form, skin appears thickened with coarse wrinkles. Etiologic, clinical, and therapeutic distinctions among different forms of photoaging remain largely unknown. To characterize the clinical, histologic, and molecular features of hypertrophic and atrophic photoaging. In total, 53 individuals were clinically classified as having primarily atrophic or hypertrophic photoaging or neither (controls). Participants' demographic and sun exposure-related lifestyle data were captured by questionnaire. Fifteen clinical features of participants were qualitatively or quantitively scored. Facial biopsies were analyzed for gene expression and histologic characteristics. Actinic and seborrheic keratosis, telangiectasia, and prior incidence of skin cancers were statistically significantly greater and photoaging scale severity, coarse wrinkles, thickness, and sallowness were significantly reduced in atrophic versus hypertrophic groups. Histology also revealed significantly less elastotic material in atrophic photoaging. Gene expression of matrix metalloproteinases and collagens did not differ between the 2 forms of photoaging. The study was not designed to identify other possible subtypes of photoaging. Systematic, categorical, and quantitative clinical and histologic assessments distinguish atrophic and hypertrophic photoaging.
Sections du résumé
BACKGROUND
BACKGROUND
Exposure to the sun causes premature skin aging, known as photoaging. Clinical features of photoaging vary widely among individuals. In one form, skin appears thin with telangiectasia, and in another form, skin appears thickened with coarse wrinkles. Etiologic, clinical, and therapeutic distinctions among different forms of photoaging remain largely unknown.
OBJECTIVE
OBJECTIVE
To characterize the clinical, histologic, and molecular features of hypertrophic and atrophic photoaging.
METHODS
METHODS
In total, 53 individuals were clinically classified as having primarily atrophic or hypertrophic photoaging or neither (controls). Participants' demographic and sun exposure-related lifestyle data were captured by questionnaire. Fifteen clinical features of participants were qualitatively or quantitively scored. Facial biopsies were analyzed for gene expression and histologic characteristics.
RESULTS
RESULTS
Actinic and seborrheic keratosis, telangiectasia, and prior incidence of skin cancers were statistically significantly greater and photoaging scale severity, coarse wrinkles, thickness, and sallowness were significantly reduced in atrophic versus hypertrophic groups. Histology also revealed significantly less elastotic material in atrophic photoaging. Gene expression of matrix metalloproteinases and collagens did not differ between the 2 forms of photoaging.
LIMITATIONS
CONCLUSIONS
The study was not designed to identify other possible subtypes of photoaging.
CONCLUSION
CONCLUSIONS
Systematic, categorical, and quantitative clinical and histologic assessments distinguish atrophic and hypertrophic photoaging.
Identifiants
pubmed: 30954583
pii: S0190-9622(19)30528-6
doi: 10.1016/j.jaad.2019.03.081
pii:
doi:
Substances chimiques
Collagen
9007-34-5
Matrix Metalloproteinases
EC 3.4.24.-
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
480-488Informations de copyright
Copyright © 2019. Published by Elsevier Inc.