Ultrafast in situ forming poly(ethylene glycol)-poly(amido amine) hydrogels with tunable drug release properties via controllable degradation rates.
Animals
Cell Line
Dendrimers
/ chemistry
Dextrans
/ administration & dosage
Drug Carriers
/ chemistry
Drug Compounding
/ methods
Drug Liberation
Drug Stability
Fibroblasts
Fluorescein-5-isothiocyanate
/ administration & dosage
Hydrogels
/ chemistry
Mice
Polyethylene Glycols
/ chemistry
Rheology
Time Factors
Toxicity Tests
Controlled drug delivery
Hydrogel
In situ formation
Poly(amido amine) dendrimer
Poly(ethylene glycol)
Tunable degradation
Journal
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
ISSN: 1873-3441
Titre abrégé: Eur J Pharm Biopharm
Pays: Netherlands
ID NLM: 9109778
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
29
09
2018
revised:
25
02
2019
accepted:
03
04
2019
pubmed:
8
4
2019
medline:
30
8
2019
entrez:
8
4
2019
Statut:
ppublish
Résumé
Fast in situ forming, chemically crosslinked hydrogels were prepared by the amidation reaction between N-succinimidyl ester end groups of multi-armed poly(ethylene glycol) (PEG) and amino surface groups of poly(amido amine) (PAMAM) dendrimer generation 2.0. To control the properties of the PEG/PAMAM hydrogels, PEGs were used with different arm numbers (4 or 8) as well as different linkers (amide or ester) between the PEG arms and their terminal N-succinimidyl ester groups. Oscillatory rheology measurements showed that the hydrogels form within seconds after mixing the PEG and PAMAM precursor solutions. The storage moduli increased with crosslink density and reached values up to 2.3 kPa for hydrogels based on 4-armed PEG. Gravimetrical degradation experiments demonstrated that hydrogels with ester linkages between PEG and PAMAM degrade within 2 days, whereas amide-linked hydrogels were stable for several months. The release of two different model drugs (fluorescein isothiocyanate-dextran with molecular weights of 4·10
Identifiants
pubmed: 30954658
pii: S0939-6411(18)31143-3
doi: 10.1016/j.ejpb.2019.04.006
pii:
doi:
Substances chimiques
Dendrimers
0
Dextrans
0
Drug Carriers
0
Hydrogels
0
PEG-PAMAM
0
fluorescein isothiocyanate dextran
0
Polyethylene Glycols
3WJQ0SDW1A
Fluorescein-5-isothiocyanate
I223NX31W9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
232-239Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.