Tumor Imaging Using Radiolabeled Matrix Metalloproteinase-Activated Anthrax Proteins.
Animals
Antigens, Bacterial
/ chemistry
Bacterial Toxins
/ chemistry
Biological Transport
Cell Line, Tumor
Humans
Indium Radioisotopes
/ chemistry
Kinetics
MCF-7 Cells
Matrix Metalloproteinase 14
/ chemistry
Matrix Metalloproteinase 2
/ chemistry
Matrix Metalloproteinases
/ metabolism
Mice
Mutation
Neoplasm Transplantation
Neoplasms
/ diagnostic imaging
Tomography, Emission-Computed, Single-Photon
MMP
SPECT
anthrax lethal toxin
cancer
pretargeting
Journal
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
22
01
2019
accepted:
13
03
2019
pubmed:
8
4
2019
medline:
14
4
2020
entrez:
8
4
2019
Statut:
ppublish
Résumé
Increased activity of matrix metalloproteinases (MMPs) is associated with worse prognosis in different cancer types. The wild-type protective antigen (PA-WT) of the binary anthrax lethal toxin was modified to form a pore in cell membranes only when cleaved by MMPs (to form PA-L1). Anthrax lethal factor (LF) is then able to translocate through these pores. Here, we used a
Identifiants
pubmed: 30954944
pii: jnumed.119.226423
doi: 10.2967/jnumed.119.226423
pmc: PMC6785798
doi:
Substances chimiques
Antigens, Bacterial
0
Bacterial Toxins
0
Indium Radioisotopes
0
anthrax toxin
0
Matrix Metalloproteinases
EC 3.4.24.-
MMP2 protein, human
EC 3.4.24.24
Matrix Metalloproteinase 2
EC 3.4.24.24
MMP14 protein, human
EC 3.4.24.80
Matrix Metalloproteinase 14
EC 3.4.24.80
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1474-1482Subventions
Organisme : Medical Research Council
ID : MR/P018661/1
Pays : United Kingdom
Informations de copyright
© 2019 by the Society of Nuclear Medicine and Molecular Imaging.
Références
Protein Eng Des Sel. 2004 Jan;17(1):21-7
pubmed: 14985534
Infect Immun. 2007 Nov;75(11):5175-84
pubmed: 17724066
Nature. 2013 Sep 5;501(7465):63-8
pubmed: 23995686
Cell. 2010 Apr 2;141(1):52-67
pubmed: 20371345
J Biol Chem. 1992 Aug 5;267(22):15542-8
pubmed: 1639793
Mol Cancer Ther. 2005 Sep;4(9):1303-10
pubmed: 16170021
Biol Pharm Bull. 2009 Jul;32(7):1272-7
pubmed: 19571397
Genes Dis. 2015 Mar 1;2(`1):26-34
pubmed: 26097889
Mol Imaging Biol. 2018 Apr;20(2):292-299
pubmed: 28842811
J Biol Chem. 1992 Aug 15;267(23):16396-402
pubmed: 1644824
J Nucl Med. 2017 Oct;58(10):1553-1559
pubmed: 28687600
PLoS One. 2017 Aug 22;12(8):e0183346
pubmed: 28829806
Contrast Media Mol Imaging. 2014 May-Jun;9(3):187-210
pubmed: 24700747
J Biol Chem. 2001 May 25;276(21):17976-84
pubmed: 11278833
Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12424-9
pubmed: 19617532
Open Vaccine J. 2009;2:92-99
pubmed: 20390054
Biochem Biophys Res Commun. 1998 Jul 30;248(3):706-11
pubmed: 9703991
J Biol Chem. 2008 Jan 4;283(1):529-40
pubmed: 17974567
Mol Med. 1998 Feb;4(2):87-95
pubmed: 9508786
Circ Res. 2003 May 2;92(8):827-39
pubmed: 12730128
PLoS One. 2010 Nov 08;5(11):e13888
pubmed: 21079738
J Alzheimers Dis. 2011;26(4):779-86
pubmed: 21694463
Infect Immun. 1998 Oct;66(10):4696-9
pubmed: 9746566
Biopolymers. 1996;40(4):399-416
pubmed: 8765610
Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17867-72
pubmed: 15601762
Infect Immun. 2005 Sep;73(9):5978-87
pubmed: 16113318
Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5170-4
pubmed: 12700348
Cancer Res. 2000 Nov 1;60(21):6061-7
pubmed: 11085528
Appl Radiat Isot. 2006 Jun;64(6):677-85
pubmed: 16546398