Periaqueductal Gray Sheds Light on Dark Areas of Psychopathology.
addiction
depression
intermittent explosive disorder
pain
survival
Journal
Trends in neurosciences
ISSN: 1878-108X
Titre abrégé: Trends Neurosci
Pays: England
ID NLM: 7808616
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
06
12
2018
revised:
26
02
2019
accepted:
07
03
2019
pubmed:
9
4
2019
medline:
17
9
2020
entrez:
9
4
2019
Statut:
ppublish
Résumé
Neurons in the periaqueductal gray (PAG) integrate negative emotions with the autonomic, neuroendocrine, and immune systems to facilitate responses to threat. Modern functional track tracing in animals and optogenetic and chemogenetic techniques show that the PAG is a rich substrate for the integration of active and passive responses to threat. In humans, the same regions of the PAG that give rise to adaptive anger/fight, fear/panic, depression/shutdown, pain, and predatory behaviors in response to challenging situations or overwhelming threats can become activated pathologically, resulting in symptoms that resemble those of psychiatric disorders. This review coalesces human and animal studies to link PAG neuropathways to specific elements of psychiatric diagnoses. The insights gained from this overview may eventually lead to new therapeutic interventions.
Identifiants
pubmed: 30955857
pii: S0166-2236(19)30038-4
doi: 10.1016/j.tins.2019.03.004
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
349-360Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.