Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development.
epistasis
functional annotation
lung cancer
oncogenesis
Journal
Oncotarget
ISSN: 1949-2553
Titre abrégé: Oncotarget
Pays: United States
ID NLM: 101532965
Informations de publication
Date de publication:
05 Mar 2019
05 Mar 2019
Historique:
received:
27
10
2018
accepted:
22
01
2019
entrez:
9
4
2019
pubmed:
9
4
2019
medline:
9
4
2019
Statut:
epublish
Résumé
The development of cancer is driven by the accumulation of many oncogenesis-related genetic alterations and tumorigenesis is triggered by complex networks of involved genes rather than independent actions. To explore the epistasis existing among oncogenesis-related genes in lung cancer development, we conducted pairwise genetic interaction analyses among 35,031 SNPs from 2027 oncogenesis-related genes. The genotypes from three independent genome-wide association studies including a total of 24,037 lung cancer patients and 20,401 healthy controls with Caucasian ancestry were analyzed in the study. Using a two-stage study design including discovery and replication studies, and stringent Bonferroni correction for multiple statistical analysis, we identified significant genetic interactions between SNPs in
Identifiants
pubmed: 30956756
doi: 10.18632/oncotarget.26678
pii: 26678
pmc: PMC6442994
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1760-1774Subventions
Organisme : NCI NIH HHS
ID : R35 CA197449
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA076292
Pays : United States
Organisme : World Health Organization
ID : 001
Pays : International
Organisme : NCI NIH HHS
ID : U01 CA167462
Pays : United States
Organisme : NCI NIH HHS
ID : U19 CA203654
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA119997
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA235464
Pays : United States
Déclaration de conflit d'intérêts
CONFLICTS OF INTEREST The authors whose names are listed above certify that they have NO affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.
Références
Int J Cancer. 2010 May 1;126(9):2199-210
pubmed: 19626602
Am J Transl Res. 2009 Jun 08;1(4):326-40
pubmed: 19956445
Nature. 2014 Jul 31;511(7511):543-50
pubmed: 25079552
Clin Cancer Res. 2006 Sep 15;12(18):5369-76
pubmed: 17000670
J Cell Physiol. 2007 Nov;213(2):374-83
pubmed: 17680632
Carcinogenesis. 2014 Mar;35(3):572-7
pubmed: 24325914
Nature. 2012 Sep 27;489(7417):519-25
pubmed: 22960745
Nat Rev Cancer. 2014 Jan;14(1):49-60
pubmed: 24505619
Nat Commun. 2014 Nov 19;5:4828
pubmed: 25407795
Cell Adh Migr. 2010 Jan-Mar;4(1):114-23
pubmed: 20139697
Carcinogenesis. 2016 Jan;37(1):96-105
pubmed: 26590902
Carcinogenesis. 2018 Sep 21;39(9):1135-1140
pubmed: 29924316
J Natl Cancer Inst. 2010 Jul 7;102(13):959-71
pubmed: 20548021
Nat Protoc. 2009;4(1):44-57
pubmed: 19131956
Nature. 1983 Aug 18-24;304(5927):596-602
pubmed: 6308472
Mol Oncol. 2007 Jun;1(1):26-41
pubmed: 19383285
Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1193-8
pubmed: 22223662
Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12111-6
pubmed: 17626182
Nat Genet. 2010 Oct;42(10):893-6
pubmed: 20871597
Carcinogenesis. 2014 Jul;35(7):1528-35
pubmed: 24658283
Oncotarget. 2017 May 23;8(21):34534-34551
pubmed: 28427185
Nat Genet. 2008 Dec;40(12):1404-6
pubmed: 18978790
Adv Exp Med Biol. 2016;890:37-56
pubmed: 26703798
Hum Genet. 2012 May;131(5):747-56
pubmed: 22143225
Nat Genet. 2008 May;40(5):616-22
pubmed: 18385676
Nat Rev Cancer. 2011 Dec 01;12(1):51-8
pubmed: 22129804
Cell. 2011 Apr 1;145(1):30-8
pubmed: 21458666
Carcinogenesis. 2007 Sep;28(9):1902-5
pubmed: 17307802
Cancer Cell. 2012 Jul 10;22(1):9-20
pubmed: 22789535
Sci Rep. 2017 Jul 11;7(1):5082
pubmed: 28698656
Nat Genet. 2017 Jul;49(7):1126-1132
pubmed: 28604730
Cancer Epidemiol Biomarkers Prev. 2018 Apr;27(4):363-379
pubmed: 28615365
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
PLoS Genet. 2012;8(11):e1003029
pubmed: 23209423
Oncotarget. 2017 Sep 6;8(53):91471-91480
pubmed: 29207658
Carcinogenesis. 2018 Mar 8;39(3):336-346
pubmed: 29059373
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
Cell. 2000 Jan 7;100(1):57-70
pubmed: 10647931
Oncotarget. 2015 Feb 10;6(4):2366-84
pubmed: 25544774
Hum Mol Genet. 2018 May 15;27(10):1819-1829
pubmed: 29547942
J Natl Cancer Inst. 2015 Oct 12;107(12):djv279
pubmed: 26464424
J Thorac Dis. 2010 Sep;2(3):154-9
pubmed: 22263037
J Biol Chem. 2009 Nov 13;284(46):31945-52
pubmed: 19783859
Cancer Biother Radiopharm. 2016 Dec;31(10):353-359
pubmed: 27996312