Soft Tissue Sarcomas of the Thoracic Wall: More Prone to Higher Mortality, and Local Recurrence-A Single Institution Long-Term Follow-up Study.
Adolescent
Adult
Aged
Aged, 80 and over
Female
Follow-Up Studies
Humans
Male
Margins of Excision
Middle Aged
Neoplasm Grading
Neoplasm Recurrence, Local
/ epidemiology
Prognosis
Registries
Retrospective Studies
Sarcoma
/ mortality
Soft Tissue Neoplasms
/ mortality
Survival Analysis
Thoracic Neoplasms
/ mortality
Thoracic Wall
/ pathology
Young Adult
Journal
International journal of surgical oncology
ISSN: 2090-1410
Titre abrégé: Int J Surg Oncol
Pays: United States
ID NLM: 101566285
Informations de publication
Date de publication:
2019
2019
Historique:
received:
29
11
2018
revised:
10
02
2019
accepted:
13
02
2019
entrez:
9
4
2019
pubmed:
9
4
2019
medline:
17
8
2019
Statut:
epublish
Résumé
This study aims to assess the impact of surgical margin and malignancy grade on overall survival (OS) and local recurrence free rate (LRFR) for soft tissue sarcomas (STS) of the thoracic wall. This retrospective cohort study identified 88 patients, diagnosed and treated surgically for a nonmetastatic STS located in the thoracic wall between 1995 and 2013, using the population based and validated Aarhus Sarcoma Registry and Danish Sarcoma Registry. The Kaplan-Meier method was used to estimate OS and LRFR. Multivariate Cox analyses were used to determine prognostic factors for OS and LRFR. The 5-year OS was 55% (95% confidence interval (CI): 0.44-0.65) and 5-year LRFR was 77% (95% CI: 0.67-0.85). High malignancy grade and intralesional/marginal resection were identified as negative predictors for OS. High grade was the only prognostic factor associated with a lower LRFR. In this large, single institution, study tumor grade was the key predictor for OS and LRFR. Surgical margin only statistically significantly influenced mortality, not local recurrence.
Identifiants
pubmed: 30956820
doi: 10.1155/2019/2350157
pmc: PMC6425367
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2350157Références
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