Biochemical effects and safety of Gum arabic (
Bilirubin
Gum arabic
Liver enzyme
Sickle cell anemia
Urea
Journal
Blood research
ISSN: 2287-979X
Titre abrégé: Blood Res
Pays: Korea (South)
ID NLM: 101605247
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
27
05
2018
revised:
13
09
2018
accepted:
01
10
2018
entrez:
9
4
2019
pubmed:
9
4
2019
medline:
9
4
2019
Statut:
ppublish
Résumé
Sickle cell anemia (SCA) is a hereditary chronic hemolytic anemia with several clinical consequences. Intravascular sickling of red blood cells leads to multi-organ dysfunction. Moreover, several biochemical abnormalities have been associated with SCA. Gum arabic (GA) is an edible dried gummy exudate obtained from Forty-seven patients (5-42 yr) carrying hemoglobin SS were recruited. The patients received 30 g/day GA for 12 weeks. Blood samples were collected before administering GA and then after 4, 8, and 12 weeks. Liver enzymes, total protein, albumin, electrolytes, urea, creatinine, and uric acid were determined in the serum. The study was approved by the Al Neelain University Institutional Review Board and Research Ethics Committee Ministry of Health. The trial was registered at ClinicalTrials.gov (identifier: NCT02467257). GA significantly decreased direct bilirubin level [statistical significance ( GA may alter the disease severity in SCA as demonstrated by its ability to decrease direct bilirubin and urea levels in the serum.
Sections du résumé
BACKGROUND
BACKGROUND
Sickle cell anemia (SCA) is a hereditary chronic hemolytic anemia with several clinical consequences. Intravascular sickling of red blood cells leads to multi-organ dysfunction. Moreover, several biochemical abnormalities have been associated with SCA. Gum arabic (GA) is an edible dried gummy exudate obtained from
METHODS
METHODS
Forty-seven patients (5-42 yr) carrying hemoglobin SS were recruited. The patients received 30 g/day GA for 12 weeks. Blood samples were collected before administering GA and then after 4, 8, and 12 weeks. Liver enzymes, total protein, albumin, electrolytes, urea, creatinine, and uric acid were determined in the serum. The study was approved by the Al Neelain University Institutional Review Board and Research Ethics Committee Ministry of Health. The trial was registered at ClinicalTrials.gov (identifier: NCT02467257).
RESULTS
RESULTS
GA significantly decreased direct bilirubin level [statistical significance (
CONCLUSION
CONCLUSIONS
GA may alter the disease severity in SCA as demonstrated by its ability to decrease direct bilirubin and urea levels in the serum.
Identifiants
pubmed: 30956961
doi: 10.5045/br.2019.54.1.31
pmc: PMC6439290
doi:
Banques de données
ClinicalTrials.gov
['NCT02467257']
Types de publication
Journal Article
Langues
eng
Pagination
31-37Déclaration de conflit d'intérêts
Authors' Disclosures of Potential Conflicts of Interest: No potential conflicts of interest relevant to this article were reported.
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