Bruton's tyrosine kinase (Btk) inhibitor tirabrutinib suppresses osteoclastic bone resorption.
Bone erosion
Bruton's tyrosine kinase
Osteoclasts
RANKL
Tec
Journal
Bone reports
ISSN: 2352-1872
Titre abrégé: Bone Rep
Pays: United States
ID NLM: 101646176
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
12
11
2018
revised:
12
02
2019
accepted:
11
03
2019
entrez:
9
4
2019
pubmed:
9
4
2019
medline:
9
4
2019
Statut:
epublish
Résumé
Osteoclasts are responsible for bone erosion in osteoporosis and rheumatoid arthritis (RA). Both Btk and Tec kinases have essential functions in osteoclast differentiation. Tirabrutinib is a highly potent and dual oral Btk/Tec inhibitor with an IC
Identifiants
pubmed: 30956999
doi: 10.1016/j.bonr.2019.100201
pii: S2352-1872(19)30007-5
pii: 100201
pmc: PMC6431727
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100201Références
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