Expression of long noncoding RNAs in breast cancer in relation to reproductive factors and tumor characteristics.
FAS-anti sense 1 (FAS-AS1)
OPA-interacting protein 5-AS1 (OIP5-AS1)
breast cancer
nuclear-enriched abundant transcript 1 (NEAT1)
taurine upregulated 1 (TUG1)
Journal
Journal of cellular biochemistry
ISSN: 1097-4644
Titre abrégé: J Cell Biochem
Pays: United States
ID NLM: 8205768
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
17
12
2018
revised:
03
02
2019
accepted:
14
02
2019
pubmed:
9
4
2019
medline:
13
8
2020
entrez:
9
4
2019
Statut:
ppublish
Résumé
Long noncoding RNAs (lncRNA) regulate expressions of several cancer-related genes and pathways. Expression profiling of lncRNAs would pave the way for identification of dysregulated pathways in cancer. We assessed expression of FAS-anti sense 1 (FAS-AS1), Taurine Upregulated 1 (TUG1), OPA-interacting protein 5-AS1 (OIP5 -AS1), nuclear-enriched abundant transcript 1 (NEAT1), and highly upregulated in liver cancer (HULC) in breast tumor tissues and adjacent noncancerous tissues (ANCTs). TUG1 was downregulated in tumoral tissues. We found associations between TUG1 expression and mitotic rate, NEAT1 expression and breast feeding duration as well as FAS-AS1 and OPI5 expressions and menarche age. A combination of transcript levels of all genes had 88.5% sensitivity and 42.3% specificity in breast cancer diagnosis. The current study provides evidence for the contribution of lncRNAs in breast cancer in relation to reproductive factors and tumor characteristics.
Substances chimiques
RNA, Long Noncoding
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13965-13973Informations de copyright
© 2019 Wiley Periodicals, Inc.