Nationally-representative serostudy of dengue in Bangladesh allows generalizable disease burden estimates.
Bangladesh
Seroprevalence
dengue
epidemiology
global health
nationally-representative
virus
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
08 04 2019
08 04 2019
Historique:
received:
15
10
2018
accepted:
04
04
2019
pubmed:
9
4
2019
medline:
29
2
2020
entrez:
9
4
2019
Statut:
epublish
Résumé
Serostudies are needed to answer generalizable questions on disease risk. However, recruitment is usually biased by age or location. We present a nationally-representative study for dengue from 70 communities in Bangladesh. We collected data on risk factors, trapped mosquitoes and tested serum for IgG. Out of 5866 individuals, 24% had evidence of historic infection, ranging from 3% in the north to >80% in Dhaka. Being male (aOR:1.8, [95%CI:1.5-2.0]) and recent travel (aOR:1.3, [1.1-1.8]) were linked to seropositivity. We estimate that 40 million [34.3-47.2] people have been infected nationally, with 2.4 million ([1.3-4.5]) annual infections. Had we visited only 20 communities, seropositivity estimates would have ranged from 13% to 37%, highlighting the lack of representativeness generated by small numbers of communities. Our findings have implications for both the design of serosurveys and tackling dengue in Bangladesh.
Identifiants
pubmed: 30958263
doi: 10.7554/eLife.42869
pii: 42869
pmc: PMC6513551
doi:
pii:
Substances chimiques
Antibodies, Viral
0
Immunoglobulin G
0
Types de publication
Journal Article
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
HS, KP, RP, IR, ZR, MA, MR, HA, JH, EG No competing interests declared
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