The Use of a Microfluidic Device to Encapsulate a Poorly Water-Soluble Drug CoQ
drug delivery system(s)
lipid nanoparticle(s) (LNP)
liposome(s)
microfluidics
nanotechnology
poorly water-soluble drug(s)
Journal
Journal of pharmaceutical sciences
ISSN: 1520-6017
Titre abrégé: J Pharm Sci
Pays: United States
ID NLM: 2985195R
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
06
03
2019
revised:
01
04
2019
accepted:
02
04
2019
pubmed:
9
4
2019
medline:
18
8
2020
entrez:
9
4
2019
Statut:
ppublish
Résumé
A number of drugs that are currently on the market, as well as new candidates for drugs, are poorly water soluble. Because of this, a need exists to develop drug formulations that will permit the expanded use of such drugs. The use of liposomes and lipid nanoparticles for drug delivery has attracted attention as a technique for solubilizing molecules that are poorly water soluble, but this technique faces serious scale-up risks. In this study, we report on attempts to encapsulate Coenzyme Q
Identifiants
pubmed: 30959057
pii: S0022-3549(19)30214-X
doi: 10.1016/j.xphs.2019.04.001
pii:
doi:
Substances chimiques
Lipids
0
Liposomes
0
Vitamins
0
Water
059QF0KO0R
Ubiquinone
1339-63-5
coenzyme Q10
EJ27X76M46
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2668-2676Informations de copyright
Copyright © 2019. Published by Elsevier Inc.