Drug therapies and delivery mechanisms to treat perturbed skin wound healing.
Chronic wound
Diabetic foot ulcer
Foam
Hydrogel
Layer by layer
Pressure ulcer
Scaffold
Sponge
Venous leg ulcer
Journal
Advanced drug delivery reviews
ISSN: 1872-8294
Titre abrégé: Adv Drug Deliv Rev
Pays: Netherlands
ID NLM: 8710523
Informations de publication
Date de publication:
Historique:
received:
16
01
2019
revised:
29
03
2019
accepted:
29
03
2019
pubmed:
9
4
2019
medline:
29
9
2020
entrez:
9
4
2019
Statut:
ppublish
Résumé
Acute wound healing is an orderly process of four overlapping events: haemostasis, inflammation, proliferation and remodelling. A drug delivery system with a temporal control of release could promote each of these events sequentially. However, acute wound healing normally proceeds very well in healthy individuals and there is little need to promote it. In the elderly and diabetics however, healing is often slow and wounds can become chronic and we need to promote their healing. Targeting the events of acute wound healing would not be appropriate for a chronic wound, which have stalled in the proinflammatory phase. They also have many additional problems such as poor circulation, low oxygen, high levels of leukocytes, high reactive oxygen species, high levels of proteolytic enzymes, high levels of proinflammatory cytokines, bacterial infection and high pH. The future challenge will be to tackle each of these negative factors to create a wound environment conducive to healing.
Identifiants
pubmed: 30959068
pii: S0169-409X(19)30042-0
doi: 10.1016/j.addr.2019.03.006
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2-18Informations de copyright
Copyright © 2019. Published by Elsevier B.V.