Effects of vitamin D supplementation on bone turnover markers and other bone-related substances in subjects with vitamin D deficiency.

Biomarkers / metabolism Bone Remodeling Calcium / blood Dietary Supplements Female Humans Male Middle Aged Parathyroid Hormone / blood Vitamin D / analogs & derivatives Vitamin D Deficiency / drug therapy
Bone turnover CTX-1 P1NP PTH Vitamin D

Journal

Bone
ISSN: 1873-2763
Titre abrégé: Bone
Pays: United States
ID NLM: 8504048

Informations de publication

Date de publication:
07 2019
Historique:
received: 25 01 2019
revised: 14 03 2019
accepted: 04 04 2019
pubmed: 9 4 2019
medline: 30 7 2020
entrez: 9 4 2019
Statut: ppublish

Résumé

In observational studies, vitamin D deficiency is a risk factor for low bone density and future fractures, whereas a causal relation has been difficult to show in randomized controlled trials (RCTs). Similarly, vitamin D deficiency has been associated with increased bone turnover, but RCTs with vitamin D have not shown conclusive effects. This could be due to inclusion of vitamin D sufficient subjects and low vitamin D doses. In the present study 399 subjects with mean baseline serum 25-hydroxyvitamin D (25(OH)D) 34.0 nmol/L completed a four months intervention with vitamin D

Identifiants

DOI: 10.1016/j.bone.2019.04.002 PMID: 30959189
pubmed: 30959189
pii: S8756-3282(19)30130-9
doi: 10.1016/j.bone.2019.04.002
pii:
doi:

Substances chimiques

Biomarkers 0
Parathyroid Hormone 0
Vitamin D 1406-16-2
25-hydroxyvitamin D A288AR3C9H
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

7-13

Informations de copyright

Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Rolf Jorde (R)

Tromsø Endocrine Research Group, Department of Clinical Medicine, UiT, The Arctic University of Norway, 9038 Tromsø, Norway; Division of Internal Medicine, University Hospital of North Norway, 9038 Tromsø, Norway. Electronic address: rolf.jorde@unn.no.

Astrid Kamilla Stunes (AK)

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. Electronic address: kamilla.stunes@ntnu.no.

Julia Kubiak (J)

Tromsø Endocrine Research Group, Department of Clinical Medicine, UiT, The Arctic University of Norway, 9038 Tromsø, Norway. Electronic address: julia.kubiak@unn.no.

Ragnar Joakimsen (R)

Tromsø Endocrine Research Group, Department of Clinical Medicine, UiT, The Arctic University of Norway, 9038 Tromsø, Norway; Division of Internal Medicine, University Hospital of North Norway, 9038 Tromsø, Norway. Electronic address: ragnar.joakimsen@unn.no.

Guri Grimnes (G)

Tromsø Endocrine Research Group, Department of Clinical Medicine, UiT, The Arctic University of Norway, 9038 Tromsø, Norway; Division of Internal Medicine, University Hospital of North Norway, 9038 Tromsø, Norway. Electronic address: guri.grimnes@unn.no.

Per Medbøe Thorsby (PM)

Hormone Laboratory, Department of Medical Biochemistry, Oslo University Hospital, Aker Hospital, Oslo, Norway. Electronic address: pertho@ous-hf.no.

Unni Syversen (U)

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. Electronic address: unni.syversen@ntnu.no.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Effects of vitamin D supplementation on bone...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Remodelage osseux › Effects of vitamin D supplementation on bone...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Effects of vitamin D supplementation on bone...
questionsmedicales.fr › Aliments et boissons › Aliments › Compléments alimentaires › Effects of vitamin D supplementation on bone...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Effects of vitamin D supplementation on bone...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Effects of vitamin D supplementation on bone...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormone parathyroïdienne › Effects of vitamin D supplementation on bone...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Sécostéroïdes › Vitamine D › Effects of vitamin D supplementation on bone...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Troubles nutritionnels › Malnutrition › Maladies de carence › Avitaminoses › Carence en vitamine D › Effects of vitamin D supplementation on bone...