An investigation into the immune response of cultured neural rat cells following Zika virus infection.
2',5'-Oligoadenylate Synthetase
/ biosynthesis
Animals
Animals, Newborn
Cells, Cultured
Cerebral Cortex
/ cytology
Female
Hippocampus
/ cytology
Interferon-beta
/ biosynthesis
Interleukin-6
/ biosynthesis
Male
Microglia
/ immunology
Myxovirus Resistance Proteins
/ biosynthesis
Neural Stem Cells
/ immunology
Rats
Viral Tropism
Zika Virus
/ pathogenicity
Zika Virus Infection
/ immunology
Brain
Cytokines
Interferon
Microglia
Rat
Zika virus
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 07 2019
15 07 2019
Historique:
received:
28
07
2018
revised:
02
04
2019
accepted:
02
04
2019
pubmed:
9
4
2019
medline:
31
3
2020
entrez:
9
4
2019
Statut:
ppublish
Résumé
The most notable effect of prenatal Zika virus (ZIKV) infection is severe microcephaly. ZIKV has a selective tropism for neural progenitor cells; however, it is not clear what role the immune cells of the brain, microglia, may have in mitigating or exacerbating neuronal cell death following ZIKV infection. We cultured hippocampal and cortical neural cells from neonatal rat pups and infected them with ZIKV at various multiplicities of infection (MOI). We found that the neuroimmune response to ZIKV infection is composed of both pro-inflammatory and type I interferon responses and is largely dependent upon the viral dose.
Identifiants
pubmed: 30959341
pii: S0165-5728(18)30349-7
doi: 10.1016/j.jneuroim.2019.04.002
pmc: PMC7350658
mid: NIHMS1603602
pii:
doi:
Substances chimiques
Il6 protein, rat
0
Interleukin-6
0
Mx1 protein, rat
0
Myxovirus Resistance Proteins
0
Interferon-beta
77238-31-4
2',5'-Oligoadenylate Synthetase
EC 2.7.7.84
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
73-77Subventions
Organisme : NICHD NIH HHS
ID : R21 HD096309
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
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