Low eicosapentaenoic acid and gamma-linolenic acid levels in breast adipose tissue are associated with inflammatory breast cancer.
Adipose samples
Breast cancer
Eicosapentaenoic acid
Inflammation
Journal
Breast (Edinburgh, Scotland)
ISSN: 1532-3080
Titre abrégé: Breast
Pays: Netherlands
ID NLM: 9213011
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
06
09
2018
revised:
24
02
2019
accepted:
01
04
2019
pubmed:
9
4
2019
medline:
4
12
2019
entrez:
9
4
2019
Statut:
ppublish
Résumé
Since it is thought that breast adipose tissue could influence breast cancer clinical presentation, we wanted to characterize specifically the relationship between breast adipose tissue fatty acid profile and Inflammatory Breast cancer (IBC). Two hundred thirty-four women presenting with breast cancer were managed in our centre between January 2009 and December 2011. Breast adipose tissue specimens were collected during breast surgery. We established the biochemical profile of adipose tissue fatty acids (FA) by gas chromatography and assessed whether there were differences in function of the presence of breast inflammation or not. We found that IBC was associated with decreased levels in breast adipose tissue of eicosapentaenoic acid (EPA), one of the two main polyunsaturated n-3 fatty acids (n-3 PUFA) of marine origin, but also with decreased levels of Gamma Linolenic acid (GLA). Inversely, an increase in palmitic acid levels was associated with IBC. These differences in lipid content may contribute to the occurrence of breast cancer inflammation.
Identifiants
pubmed: 30959386
pii: S0960-9776(19)30481-3
doi: 10.1016/j.breast.2019.04.001
pii:
doi:
Substances chimiques
gamma-Linolenic Acid
78YC2MAX4O
Eicosapentaenoic Acid
AAN7QOV9EA
Types de publication
Evaluation Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113-117Informations de copyright
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