1,2,4-Oxadiazole/2-Imidazoline Hybrids: Multi-target-directed Compounds for the Treatment of Infectious Diseases and Cancer.
Anti-Bacterial Agents
/ chemistry
Bacteria
/ drug effects
Cell Death
/ drug effects
Cell Line, Tumor
Cell Survival
/ drug effects
Communicable Diseases
/ drug therapy
Humans
Imidazoles
/ chemical synthesis
Microbial Sensitivity Tests
Monoamine Oxidase Inhibitors
/ pharmacology
Neoplasms
/ drug therapy
Oxadiazoles
/ chemical synthesis
1,2,4-oxadiazole
2-imidazolines
MAO inhibition
antibacterial
cytotoxicity
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
05 Apr 2019
05 Apr 2019
Historique:
received:
28
02
2019
revised:
31
03
2019
accepted:
03
04
2019
entrez:
10
4
2019
pubmed:
10
4
2019
medline:
25
7
2019
Statut:
epublish
Résumé
Replacement of amide moiety with the 1,2,4-oxadiazole core in the scaffold of recently reported efflux pump inhibitors afforded a novel series of oxadiazole/2-imidazoline hybrids. The latter compounds exhibited promising antibacterial activity on both Gram-positive (
Identifiants
pubmed: 30959765
pii: ijms20071699
doi: 10.3390/ijms20071699
pmc: PMC6480344
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Imidazoles
0
Monoamine Oxidase Inhibitors
0
Oxadiazoles
0
2-imidazoline
D36R5YLK6R
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Russian Foundation for Basic Research
ID : 18-33-01108
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