Inflammation and Endotyping in Chronic Rhinosinusitis-A Paradigm Shift.
CRS
chronic rhinosinusitis
endotyping
inflammation
Journal
Medicina (Kaunas, Lithuania)
ISSN: 1648-9144
Titre abrégé: Medicina (Kaunas)
Pays: Switzerland
ID NLM: 9425208
Informations de publication
Date de publication:
05 Apr 2019
05 Apr 2019
Historique:
received:
19
02
2019
revised:
28
03
2019
accepted:
01
04
2019
entrez:
10
4
2019
pubmed:
10
4
2019
medline:
29
10
2019
Statut:
epublish
Résumé
Chronic rhinosinusitis (CRS) is a heterogeneous chronic inflammatory condition of the paranasal sinuses and nasal passage. It is characterized as inflammation of the sinonasal passage, presenting with two or more symptoms (nasal blockage, secretions, facial pain and headaches) for more than 12 weeks consecutively. The disease is phenotypically differentiated based on the presence of nasal polyps; CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). Traditionally, CRSwNP has been associated with a type 2 inflammatory profile, while CRSsNP has been associated with a type 1 inflammatory profile. Extensive work in characterizing the inflammatory profiles of CRS patients has challenged this dichotomy, with great variation both between and within populations described. Recent efforts of endotyping CRS based on underlying pathophysiology have further highlighted the heterogeneity of the disease, revealing mixed inflammatory profiles coordinated by a number of inflammatory cell types. This review will highlight the current understanding of inflammation in CRS, and discuss the importance and impact of refining this understanding in the development of appropriate treatment options for CRS sufferers.
Identifiants
pubmed: 30959833
pii: medicina55040095
doi: 10.3390/medicina55040095
pmc: PMC6524025
pii:
doi:
Substances chimiques
Biomarkers
0
Cytokines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
Am J Respir Crit Care Med. 2015 Sep 15;192(6):682-94
pubmed: 26067893
Otolaryngol Head Neck Surg. 2007 Sep;137(3 Suppl):S1-31
pubmed: 17761281
Am J Rhinol Allergy. 2011 Jul-Aug;25(4):209-13
pubmed: 21819755
Nat Immunol. 2013 Jun;14(6):536-42
pubmed: 23685824
J Allergy Clin Immunol. 2012 Nov;130(5):1087-1096.e10
pubmed: 22840853
Front Immunol. 2018 Sep 19;9:2065
pubmed: 30283438
Expert Opin Biol Ther. 2019 Jan;19(1):45-54
pubmed: 30500317
Immunity. 2006 Feb;24(2):179-89
pubmed: 16473830
Laryngoscope. 2012 Feb;122(2):467-72
pubmed: 22253013
J Immunol. 2007 Jul 15;179(2):1080-7
pubmed: 17617600
J Allergy Clin Immunol. 2009 Aug;124(2):253-9, 259.e1-2
pubmed: 19500825
Adv Exp Med Biol. 2014;841:209-30
pubmed: 25261209
Front Cell Infect Microbiol. 2018 Feb 28;8:57
pubmed: 29541629
Allergo J Int. 2018;27(2):56-65
pubmed: 29564208
MAbs. 2015;7(3):605-19
pubmed: 25764208
Int Forum Allergy Rhinol. 2012 Mar-Apr;2(2):104-10
pubmed: 22253045
Am J Respir Crit Care Med. 2013 Aug 15;188(4):432-9
pubmed: 23805875
J Allergy Clin Immunol. 2011 Nov;128(5):989-95.e1-8
pubmed: 21958585
J Allergy Clin Immunol. 2016 May;137(5):1449-1456.e4
pubmed: 26949058
J Allergy Clin Immunol. 2015 Dec;136(6):1454-1459
pubmed: 26654194
PLoS One. 2015 Aug 14;10(8):e0136068
pubmed: 26275068
J Allergy Clin Immunol. 2016 Nov;138(5):1344-1353
pubmed: 27544740
BMB Rep. 2018 Feb;51(2):59-64
pubmed: 29366441
Int Forum Allergy Rhinol. 2015 Jun;5(6):551-6
pubmed: 25821008
J Allergy Clin Immunol. 2017 Oct;140(4):1024-1031.e14
pubmed: 28687232
Cell Mol Immunol. 2012 Sep;9(5):375-9
pubmed: 22659733
Sci Transl Med. 2012 Sep 12;4(151):151ra124
pubmed: 22972842
Rhinology. 2012 Mar;50(1):1-12
pubmed: 22469599
Allergy. 2014 Apr;69(4):517-26
pubmed: 24611950
Nat Rev Immunol. 2019 May;19(5):305-323
pubmed: 30858494
Rhinology. 2010 Mar;48(1):54-8
pubmed: 20502736
Clin Exp Allergy. 2016 Jan;46(1):21-41
pubmed: 26510171
Am J Respir Crit Care Med. 2018 Aug 15;198(4):452-463
pubmed: 29768034
J Allergy Clin Immunol. 2016 Apr;137(4):1054-1062
pubmed: 26806047
J Allergy Clin Immunol. 2018 May;141(5):1543-1551
pubmed: 29731100
J Proteomics. 2017 Feb 23;155:31-39
pubmed: 28099884
Microbiome. 2014 Jun 25;2:22
pubmed: 25028608
Respir Res. 2014 Feb 18;15:21
pubmed: 24548792
Eur Arch Otorhinolaryngol. 2001 Oct;258(8):406-12
pubmed: 11724263
PLoS One. 2013 Dec 30;8(12):e85507
pubmed: 24386477
Immunity. 2001 Dec;15(6):985-95
pubmed: 11754819
Expert Rev Clin Immunol. 2006 May;2(3):331-40
pubmed: 20476905
Int Rev Cell Mol Biol. 2013;303:139-202
pubmed: 23445810
Allergol Int. 2015 Apr;64(2):121-30
pubmed: 25838086
J Allergy Clin Immunol. 2009 Sep;124(3):478-84, 484.e1-2
pubmed: 19541359
J Allergy Clin Immunol Pract. 2016 Jul-Aug;4(4):621-8
pubmed: 27393777
Allergy. 2006 Nov;61(11):1280-9
pubmed: 17002703
Allergy. 2019 Jan;74(1):131-140
pubmed: 29802623
Microbiome. 2017 May 12;5(1):53
pubmed: 28494786
Ann N Y Acad Sci. 2013 Apr;1283:8-12
pubmed: 23402657
J Allergy Clin Immunol. 2004 Oct;114(4):981-3
pubmed: 15480349
J Allergy Clin Immunol. 2008 Nov;122(5):961-8
pubmed: 18804271
J Clin Invest. 2002 Mar;109(5):571-7
pubmed: 11877463
Allergy. 2018 Jul;73(7):1459-1469
pubmed: 29331025
J Allergy Clin Immunol. 2017 Feb;139(2):699-703.e7
pubmed: 27639939
J Immunol. 2007 Feb 1;178(3):1396-404
pubmed: 17237387
Am J Rhinol Allergy. 2016 Nov 1;30(6):202-205
pubmed: 28124641
J Infect Dis. 1999 Sep;180(3):737-46
pubmed: 10438362
Am J Physiol Cell Physiol. 2004 Jun;286(6):C1213-28
pubmed: 15151915
Eur Arch Otorhinolaryngol. 2016 Jul;273(7):1779-88
pubmed: 26518209
JAMA. 2016 Feb 2;315(5):469-79
pubmed: 26836729
Acta Otolaryngol. 2013 Feb;133(2):165-73
pubmed: 23157229
Respir Med. 2014 Oct;108(10):1409-23
pubmed: 25240764
Immunity. 2005 Nov;23(5):479-90
pubmed: 16286016
J Allergy Clin Immunol. 1995 Oct;96(4):537-44
pubmed: 7560666
J Allergy Clin Immunol. 2018 May;141(5):1895-1897.e7
pubmed: 29452200
Int Forum Allergy Rhinol. 2015 May;5(5):399-407
pubmed: 25694390
J Allergy Clin Immunol. 2008 Jun;121(6):1435-41, 1441.e1-3
pubmed: 18423831
J Allergy Clin Immunol. 2015 Dec;136(6):1548-1558.e7
pubmed: 26143180
J Allergy Clin Immunol. 2015 Dec;136(6):1442-1453
pubmed: 26654193