Effect of the Phosphodiesterase 5 Inhibitor Sildenafil on Ischemia-Reperfusion-Induced Muscle Mitochondrial Dysfunction and Oxidative Stress.
calcic retention capacity
cyclic nucleotide phosphodiesterase
ischemia
mitochondria
muscle
oxidative stress
peripheral arterial disease
reactive oxygen species
reperfusion
sildenafil
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
07 Apr 2019
07 Apr 2019
Historique:
received:
28
03
2019
revised:
04
04
2019
accepted:
05
04
2019
entrez:
10
4
2019
pubmed:
10
4
2019
medline:
10
4
2019
Statut:
epublish
Résumé
Lower-limb ischemia-reperfusion (IR) is frequent and associated with significant morbidity and mortality. Phosphodiesterase 5 inhibitors demonstrated antioxidant and beneficial effects in several organs submitted to IR, but their effects on muscle mitochondrial functions after lower-limb IR are unknown. Unilateral hindlimb IR (2 h tourniquet followed by 2 h reperfusion) without or with sildenafil (1mg/kg ip 30 minutes before ischemia) was performed in 18 mice. Maximal oxidative capacity (V
Identifiants
pubmed: 30959961
pii: antiox8040093
doi: 10.3390/antiox8040093
pmc: PMC6523910
pii:
doi:
Types de publication
Journal Article
Langues
eng
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