Supramolecular Cyclodextrin-Based Hydrogels for Controlled Gene Delivery.
controlled gene delivery
cyclodextrin-based polypseudorotaxane hydrogels
gene transfer
nonviral vectors
supramolecular hydrogels
viral vectors
Journal
Polymers
ISSN: 2073-4360
Titre abrégé: Polymers (Basel)
Pays: Switzerland
ID NLM: 101545357
Informations de publication
Date de publication:
19 Mar 2019
19 Mar 2019
Historique:
received:
06
03
2019
revised:
15
03
2019
accepted:
17
03
2019
entrez:
10
4
2019
pubmed:
10
4
2019
medline:
10
4
2019
Statut:
epublish
Résumé
Controlled delivery of gene transfer vectors is a powerful strategy to enhance the temporal and spatial presentation of therapeutic agents in a defined target. Hydrogels are adapted biomaterials for gene delivery capable of acting as a localized depot of genes while maintaining the long term local availability of DNA vectors at a specific location. Supramolecular hydrogels based on cyclodextrins (CDs) have attracted considerable attention as potential biomaterials in a broad range of drug delivery applications. Their unique characteristics of thixotropicity and low cytotoxicity due to their production under mild conditions make them potential candidates to form injectable delivery systems. This work aims to provide an overview of the use of CD-based polypseudorotaxane hydrogels as controlled gene delivery systems for different applications in regenerative medicine.
Identifiants
pubmed: 30960498
pii: polym11030514
doi: 10.3390/polym11030514
pmc: PMC6473339
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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