Radiation Therapy Impact on Lymph Node Yield in Patients With Laryngeal Squamous Cell Carcinoma.
Aged
Atrophy
Carcinoma, Squamous Cell
/ pathology
Female
Fibrosis
Humans
Laryngeal Neoplasms
/ pathology
Lymph Nodes
/ pathology
Male
Middle Aged
Neck Dissection
/ methods
Neoplasm Staging
Outcome Assessment, Health Care
Preoperative Care
/ methods
Radiotherapy
/ adverse effects
Salvage Therapy
/ methods
laryngeal cancer
lymph node
neck dissection
radiation therapy
squamous cell carcinoma
Journal
Ear, nose, & throat journal
ISSN: 1942-7522
Titre abrégé: Ear Nose Throat J
Pays: United States
ID NLM: 7701817
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
pubmed:
10
4
2019
medline:
27
12
2019
entrez:
10
4
2019
Statut:
ppublish
Résumé
A lymph node yield (LNY) over 20 is considered a quality metric for lateral neck dissection to ensure an oncologic representative sample. Anecdotally, however, LNY in patients undergoing neck dissection after radiation therapy (RT) is lower due to atrophy and fibrosis. To determine whether preoperative RT decreases LNY in patients with laryngeal cancers undergoing surgery. Medical record database was queried for patients presenting between 2006 and 2015 with laryngeal cancer. Tabulation was made for location (glottic/supraglottic), stage, and side for the total number of lymph nodes between primary surgery and RT (salvage surgery) groups. Descriptive analysis and a paired Student Fifty-nine patients were included in the study for a total of 98 neck dissections. Twenty-six (44%) patients had primary surgery, and 33 (56%) patients had salvage surgery. The mean left and right total LNY in the salvage surgery group was 27.6 and 29.5, respectively, and 32.2 and 33.7 for the primary surgery group. A difference of 4.5 (left) and 4.3 (right) in LNY between the salvage surgery and primary surgery group was found. A Student Although patients with prior RT had a lower mean of LNY, our results did not demonstrate a statistically significant difference. Further studies with a larger number of patients are recommended.
Sections du résumé
BACKGROUND
BACKGROUND
A lymph node yield (LNY) over 20 is considered a quality metric for lateral neck dissection to ensure an oncologic representative sample. Anecdotally, however, LNY in patients undergoing neck dissection after radiation therapy (RT) is lower due to atrophy and fibrosis.
OBJECTIVE
OBJECTIVE
To determine whether preoperative RT decreases LNY in patients with laryngeal cancers undergoing surgery.
METHODS
METHODS
Medical record database was queried for patients presenting between 2006 and 2015 with laryngeal cancer. Tabulation was made for location (glottic/supraglottic), stage, and side for the total number of lymph nodes between primary surgery and RT (salvage surgery) groups. Descriptive analysis and a paired Student
RESULTS
RESULTS
Fifty-nine patients were included in the study for a total of 98 neck dissections. Twenty-six (44%) patients had primary surgery, and 33 (56%) patients had salvage surgery. The mean left and right total LNY in the salvage surgery group was 27.6 and 29.5, respectively, and 32.2 and 33.7 for the primary surgery group. A difference of 4.5 (left) and 4.3 (right) in LNY between the salvage surgery and primary surgery group was found. A Student
CONCLUSION
CONCLUSIONS
Although patients with prior RT had a lower mean of LNY, our results did not demonstrate a statistically significant difference. Further studies with a larger number of patients are recommended.
Identifiants
pubmed: 30961371
doi: 10.1177/0145561319839790
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM